Slc7a5-flox 基因敲除小鼠

1. Najumudeen, Arafath K, Ceteci, Fatih, Fey, Sigrid K, Campbell, Andrew D, Sansom, Owen J. 2021. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. In Nature genetics, 53, 16-26. doi:10.1038/s41588-020-00753-3. https://pubmed.ncbi.nlm.nih.gov/33414552/

2. Cheng, Hongcheng, Qiu, Yajing, Xu, Yue, Zhang, Lianjun, Li, Guideng. 2023. Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness. In Nature metabolism, 5, 314-330. doi:10.1038/s42255-022-00730-6. https://pubmed.ncbi.nlm.nih.gov/36717749/

3. Tărlungeanu, Dora C, Deliu, Elena, Dotter, Christoph P, Gleeson, Joseph G, Novarino, Gaia. . Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder. In Cell, 167, 1481-1494.e18. doi:10.1016/j.cell.2016.11.013. https://pubmed.ncbi.nlm.nih.gov/27912058/

4. Huang, Renhong, Wang, Han, Hong, Jin, Shen, Kunwei, Wang, Zheng. 2023. Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer. In Frontiers in immunology, 14, 1251643. doi:10.3389/fimmu.2023.1251643. https://pubmed.ncbi.nlm.nih.gov/37731509/