智鼠故事 
C57BL/6NCya-Nr1h4em1/Cya 全身性基因敲除小鼠
复苏/繁育服务
产品名称
Nr1h4-KO
产品编号
S-KO-04173
品系全称
C57BL/6NCya-Nr1h4em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-20186-Nr1h4-B6N-VA
品系状态
使用本品系发表的文献需注明： Nr1h4-KO mice (Strain S-KO-04173) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Fxr，HRR1，RIP14，Rxrip14
NCBI ID
染色体号
Chr 10
NCBI RefSeq
NM_009108
Ensembl ID
ENSMUST00000058126
修饰方式
全身性基因敲除
靶向范围
Exon 3~4
敲除长度
~3.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1352464Mice homozygous for knock-out alleles exhibit increased bile salts and abnormal liver morphology and physiology. Mice homozygous for one knock-out allele also exhibit abnormal lipid homeostasis.
发表文献
Phytomedicine
2024-01-01
Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress
Biomedicine & Pharmacotherapy
2022-04-02
Obeticholic acid inhibits hepatic fatty acid uptake independent of FXR in mouse
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