智鼠故事 
C57BL/6JCya-Bmal1em1flox/Cya 条件性基因敲除小鼠
复苏/繁育服务
产品名称
Bmal1-flox
产品编号
S-CKO-01309
品系全称
C57BL/6JCya-Bmal1em1flox/Cya
品系背景
C57BL/6JCya
品系编号
CKOCMP-11865-Bmal1-B6J-VA
品系状态
使用本品系发表的文献需注明： Bmal1-flox mice (Strain S-CKO-01309) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
MOP3，Arnt3，Arntl，BMAL1b，bHLHe5，bmal1b'
NCBI ID
染色体号
Chr 7
NCBI RefSeq
NM_007489
Ensembl ID
ENSMUST00000047321
修饰方式
条件性基因敲除
靶向范围
Exon 6~8
敲除长度
~2.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1096381Homozygous mutation of this gene results in abnormal light/dark cycle activity and decreases overall activity levels. Mice homozygous for another knock-out allele exhibit loss of circadian rhythm in locomotor activity, dyslipidemia, ectopic fat formationand altered energy homeostasis.
发表文献
Nature Metabolism
2024-04-01
Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells
Nutrients
2023-05-30
Liver-Specific Bmal1 Depletion Reverses the Beneficial Effects of Nobiletin on Liver Cholesterol Homeostasis in Mice Fed with High-Fat Diet
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