智鼠故事 
Ccr7-EGFP-loxP-Stop-loxP-DTR 小鼠
复苏/繁育服务
产品名称：
Ccr7-EGFP-loxP-Stop-loxP-DTR 小鼠
产品编号：
C001749
品系背景：
C57BL/6JCya
表达组织/细胞举例：
T细胞、树突状细胞、B细胞、NK细胞、脾脏及Ccr7阳性细胞
* 使用本品系发表的文献需注明：Ccr7-EGFP-loxP-Stop-loxP-DTR 小鼠 mice (Catalog C001749) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
Ccr7-EGFP-loxP-Stop-loxP-DTR小鼠是通过基因编辑技术将小鼠Ccr7基因TAG终止密码子替换为P2A-EGFP-IRES-loxP-6xSV40 pA-loxP-DTR基因表达元件获得的。DTR（白喉毒素受体）基因上游存在一个loxP-Stop-loxP元件框，阻断DTR的转录及表达。在未引入Cre重组酶时，Ccr7启动子驱动EGFP表达，使Ccr7阳性细胞显示绿色荧光。在Cre重组之后，Cre重组酶介导表达终止元件（LSL）的删除将导致DTR在Cre阳性细胞中的表达，注射白喉毒素（DT）可选择性清除这些细胞。
相关疾病：
Chronic Graft Versus Host Disease
Tetanus
Pars Planitis
Erdheim-Chester Disease
Lymphadenitis
Peripheral T-Cell Lymphoma
Lymphoma
B-Lymphoblastic Leukemia/lymphoma
Common Variable Immunodeficiency
Primary Central Nervous System Lymphoma
Multiple Sclerosis
Pulmonary Fibrosis
Nasopharyngeal Carcinoma
Human Immunodeficiency Virus Infectious Disease
Systemic Lupus Erythematosus
Malaria
Mycobacterium Tuberculosis 1
Leukemia, Chronic Lymphocytic
Colorectal Cancer
Rheumatoid Arthritis
Psoriasis
Yellow Fever
Gastric Cancer
Whim Syndrome 1
Human Immunodeficiency Virus Type 1
Asthma
Ovarian Cancer
Lung Cancer
Pancreatic Cancer
Immunodeficiency 49
Squamous Cell Carcinoma, Head and Neck
Immune Deficiency Disease
Combined Immunodeficiency
Primary Bacterial Infectious Disease
Interstitial Lung Disease 2
Hepatocellular Carcinoma
Lymphoma, Non-Hodgkin, Familial
Sezary's Disease
Leukemia, Chronic Myeloid
Skin Disease
Connective Tissue Disease
Nervous System Disease
