Trhr-flox 基因敲除小鼠

1. García, S I, Porto, P I, Dieuzeide, G, Gonzalez, C, Pirola, C J. . Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. In Hypertension (Dallas, Tex. : 1979), 38, 683-7. doi:. https://pubmed.ncbi.nlm.nih.gov/11566956/

2. Liu, Xiao-Gang, Tan, Li-Jun, Lei, Shu-Feng, Papasian, Christopher J, Deng, Hong-Wen. 2009. Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. In American journal of human genetics, 84, 418-23. doi:10.1016/j.ajhg.2009.02.004. https://pubmed.ncbi.nlm.nih.gov/19268274/

3. García, Marta, González de Buitrago, Jesús, Jiménez-Rosés, Mireia, Hinkle, Patricia M, Moreno, José C. . Central Hypothyroidism Due to a TRHR Mutation Causing Impaired Ligand Affinity and Transactivation of Gq. In The Journal of clinical endocrinology and metabolism, 102, 2433-2442. doi:10.1210/jc.2016-3977. https://pubmed.ncbi.nlm.nih.gov/28419241/

4. Lunardi, Cláudia C, Lima, Ricardo M, Pereira, Rinaldo W, Siqueira, Ana B M, Oliveira, Ricardo J. 2013. Association between polymorphisms in the TRHR gene, fat-free mass, and muscle strength in older women. In Age (Dordrecht, Netherlands), 35, 2477-83. doi:10.1007/s11357-013-9526-y. https://pubmed.ncbi.nlm.nih.gov/23543262/