Lpp,全称为Lipoma preferred partner,是一种在多种生物学过程中发挥重要作用的基因。Lpp编码的蛋白参与多种生物学过程,包括细胞迁移、侵袭、淋巴转移等,并与多种疾病的发生和发展密切相关。
研究表明,Lpp基因多态性与多种疾病的风险和预后相关。例如,Lpp rs1064607、rs3796283和rs2378456等基因多态性与胶质瘤的发生和发展相关,其中Lpp rs2378456 CC基因型增加了胶质瘤的风险[1]。Lpp基因还与膀胱癌的淋巴转移相关,UBE2S与TRIM21相互作用,通过K11连接的泛素化降解LPP,从而促进膀胱癌的淋巴转移[2]。此外,Lpp基因多态性还与乳糜泻、免疫球蛋白A肾病、多囊卵巢综合征等疾病的发生和发展相关[3][4][5]。
综上所述,Lpp基因在多种生物学过程中发挥重要作用,其基因多态性与多种疾病的风险和预后相关。深入研究Lpp基因的功能和作用机制,有助于揭示疾病的发生和发展机制,为疾病的治疗和预防提供新的思路和策略。
参考文献:
1. Chen, Qu, Sun, Yao, Wu, Jiamin, Jin, Tianbo, Zhao, Qiujian. 2019. LPP and RYR2 Gene Polymorphisms Correlate with the Risk and the Prognosis of Astrocytoma. In Journal of molecular neuroscience : MN, 69, 628-635. doi:10.1007/s12031-019-01391-z. https://pubmed.ncbi.nlm.nih.gov/31440994/
2. Xiao, Kanghua, Peng, Shengmeng, Lu, Junlin, Chen, Xu, Lin, Tianxin. 2023. UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer. In Cell death & disease, 14, 408. doi:10.1038/s41419-023-05938-2. https://pubmed.ncbi.nlm.nih.gov/37422473/
3. Zulfiqar, Sumaira, Fiaz, Amna, Khan, Waqas Ahmed, Ali, Basharat, Masood, Muhammad Adnan. 2024. Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan. In Genes, 15, . doi:10.3390/genes15070852. https://pubmed.ncbi.nlm.nih.gov/39062631/
4. Kerkemeyer, Karolina L S, Eisman, Samantha, Bhoyrul, Bevin, Pinczewski, Joel, Sinclair, Rodney D. 2020. Frontal fibrosing alopecia. In Clinics in dermatology, 39, 183-193. doi:10.1016/j.clindermatol.2020.10.007. https://pubmed.ncbi.nlm.nih.gov/34272007/
5. Chen, Bo, Zhang, Guochun, Li, Xuerui, Lizaso, Analyn, Liao, Ning. 2020. Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer. In Aging, 12, 3140-3155. doi:10.18632/aging.102783. https://pubmed.ncbi.nlm.nih.gov/32091409/