Sfrp1基因,即分泌型Frizzled相关蛋白1基因,属于分泌型糖蛋白SFRP家族,其编码的蛋白通过Wnt信号通路参与调节多种生理过程。Sfrp1基因在多种癌症中表达下调,主要归因于表观遗传失活,如DNA甲基化和转录沉默。研究表明,Sfrp1基因的表观遗传沉默可能与细胞增殖、迁移和侵袭的失调有关,进而导致癌症的发生、进展、不良预后和治疗耐药。
Sfrp1基因在多种癌症中发挥重要作用。例如,在结直肠癌中,Sfrp1基因启动子高甲基化与淋巴结浸润和不良预后相关[1]。在卵巢癌中,Sfrp1基因启动子高甲基化导致蛋白表达下调,参与肿瘤的发生和发展[4]。在儿童急性淋巴细胞白血病中,Sfrp1基因启动子高甲基化与疾病进展和不良预后相关[5]。此外,Sfrp1基因在食管癌、肾癌和胰腺癌中也被发现与肿瘤的发生和发展相关[6][7][8]。
除了作为肿瘤抑制基因,Sfrp1基因还可能具有致癌作用。一些研究发现,Sfrp1基因在癌症中表达上调,可能通过促进肿瘤的发生和发展发挥致癌作用[2]。此外,Sfrp1基因的表达还可能受到炎症和免疫反应的影响,参与癌症的进展[3][6]。
综上所述,Sfrp1基因在多种癌症中发挥重要作用,其表达和功能可能受到表观遗传调控、炎症和免疫反应等因素的影响。Sfrp1基因的研究有助于深入理解癌症的发生和发展机制,为癌症的治疗和预防提供新的思路和策略。未来研究可以进一步探讨Sfrp1基因在不同癌症中的功能和机制,以及其在癌症诊断和预后评估中的应用价值。
参考文献:
1. Kumar, Alok, Gosipatala, Sunil Babu, Pandey, Anshuman, Singh, Pradyumn. 2019. Prognostic Relevance of SFRP1 Gene Promoter Methylation in Colorectal Carcinoma. In Asian Pacific journal of cancer prevention : APJCP, 20, 1571-1577. doi:. https://pubmed.ncbi.nlm.nih.gov/31128064/
2. Baharudin, Rashidah, Tieng, Francis Yew Fu, Lee, Learn-Han, Ab Mutalib, Nurul Syakima. 2020. Epigenetics of SFRP1: The Dual Roles in Human Cancers. In Cancers, 12, . doi:10.3390/cancers12020445. https://pubmed.ncbi.nlm.nih.gov/32074995/
3. Gregory, Kelly J, Roberts, Amy L, Conlon, Erin M, Schneider, Sallie S, Jerry, D Joseph. 2019. Gene expression signature of atypical breast hyperplasia and regulation by SFRP1. In Breast cancer research : BCR, 21, 76. doi:10.1186/s13058-019-1157-5. https://pubmed.ncbi.nlm.nih.gov/31248446/
4. Kardum, Vedran, Karin, Valentina, Glibo, Mislav, Vranic, Semir, Serman, Ljiljana. 2017. Methylation-associated silencing of SFRP1 gene in high-grade serous ovarian carcinomas. In Annals of diagnostic pathology, 31, 45-49. doi:10.1016/j.anndiagpath.2017.07.002. https://pubmed.ncbi.nlm.nih.gov/29146058/
5. Yan, Jing, Wang, Wen-Peng, Li, Xuan, Qi, Feng-Qi, Gao, Ji-Zhao. . [Clinical Significance of SFRP1 Gene Methylation in Patients with Childhood Acute Lymphoblastic Leukemia]. In Zhongguo shi yan xue ye xue za zhi, 31, 377-382. doi:10.19746/j.cnki.issn.1009-2137.2023.02.010. https://pubmed.ncbi.nlm.nih.gov/37096508/
6. Marella, Sahiti, Sharma, Ankit, Ganesan, Varsha, Chehade, Mirna, Hogan, Simon P. 2023. IL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis. In The Journal of allergy and clinical immunology, 152, 1550-1568. doi:10.1016/j.jaci.2023.07.021. https://pubmed.ncbi.nlm.nih.gov/37652141/
7. Meng, Ying, Wang, Qing-Gang, Wang, Jun-Xiong, Li, Peng, Zhang, Shu-tian. 2011. Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. In Digestive diseases and sciences, 56, 3195-203. doi:10.1007/s10620-011-1734-7. https://pubmed.ncbi.nlm.nih.gov/21567192/
8. Mo, Shijie, Su, Zexuan, Heng, Baoli, Du, Xinghua, Lai, Caiyong. . SFRP1 Promoter Methylation and Renal Carcinoma Risk: A Systematic Review and Meta-Analysis. In Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 85, 78-86. doi:10.1272/jnms.2018_85-13. https://pubmed.ncbi.nlm.nih.gov/29731501/