智鼠故事 
Ldha-flox 基因敲除小鼠
复苏/繁育服务
产品名称
Ldha-flox 基因敲除小鼠
产品编号
S-CKO-03369
品系全称
C57BL/6JCya-Ldhaem1flox/Cya
品系背景
C57BL/6JCya
品系编号
CKOCMP-16828-Ldha-B6J-VA
品系状态
使用本品系发表的文献需注明： Ldha-flox 基因敲除小鼠 mice (Strain S-CKO-03369) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
lactate dehydrogenase A
基因别称
Ldh1，Ldhm，l7R2
染色体号
Chr 7 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_001136069 | Ensembl: ENSMUST00000209984
修饰方式
条件性基因敲除
靶向范围
Exon 3
敲除长度
~0.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:96759Mice homozygous for one chemically induced mutation exhibit severe hemolytic anemia with pronounced reticulocytosis and hyperbilirubinemia. Another mutation results in prenatal lethality in homozygotes.
发表文献
Nature Communications
2025-12-10
Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritis
Nature
2024-09-24
AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
Cell
2024-04-21
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
1
发表文献
点击查看发表文献 >>
