智鼠故事 
Ctnnb1-flox 基因敲除小鼠
复苏/繁育服务
产品名称
Ctnnb1-flox 基因敲除小鼠
产品编号
S-CKO-01559
品系全称
C57BL/6NCya-Ctnnb1em1flox/Cya
品系背景
C57BL/6NCya
品系编号
CKOCMP-12387-Ctnnb1-B6N-VA
品系状态
使用本品系发表的文献需注明： Ctnnb1-flox 基因敲除小鼠 mice (Strain S-CKO-01559) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
catenin (cadherin associated protein), beta 1
基因别称
Bfc，Mesc，Catnb
染色体号
Chr 9 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_007614 | Ensembl: ENSMUST00000007130
修饰方式
条件性基因敲除
靶向范围
Exon 7
敲除长度
~0.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:88276Homozygous null embryos show anterior-posterior axis formation anomalies, but develop to E7. Multiple conditional mutations have shown defects in distinct stem cell types that result in proliferation defects, such as intestinal polyps, brain and spinal cord size anomalies, etc. Inducible KO in endothelial cells affects retinal angiogenesis.
发表文献
Nature Communications
2025-12-04
Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice
Journal of Extracellular Vesicles
2022-02-27
β-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis
1
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