MGI:88355Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape, and abnormal embryo turning. Homozygosity for proteolytic cleavage resistance mutations affects hippocampus pyramidal neuron synapse morphology and physiology, leading to fear generalization and enhanced spatial working memory.