Angpt4-KO 基因敲除小鼠

下单100%中奖,最高可得千元京东卡
复苏/繁育服务
产品名称

Angpt4-KO 基因敲除小鼠

产品编号

S-KO-19233

品系全称

C57BL/6JCya-Angpt4em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-11602-Angpt4-B6J-VB

品系状态

使用本品系发表的文献需注明: Angpt4-KO 基因敲除小鼠 mice (Strain S-KO-19233) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
KO小鼠库模型
MAPK信号通路
PI3K-Akt信号通路

基本信息

基因研究概述

质控标准

基因
基因全称
angiopoietin 4
基因别称
ANG-3,ANG-4,Agpt4,Ang3
染色体号
Chr 2 (Mouse)
转录本 ID
NCBI: NM_009641 | Ensembl: ENSMUST00000028955
修饰方式
全身性基因敲除
靶向范围
Exon 2~3
敲除长度
~3.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
Angpt4,也称为Angiopoietin-4,是一种重要的血管生成因子,参与血管形成和血管稳定性的调节。Angpt4通过与内皮细胞上的Tie2受体结合,调节血管内皮细胞的存活、迁移和血管重塑。此外,Angpt4还参与炎症反应和免疫调节,影响多种生物学过程。

Angpt4在多种疾病中发挥重要作用。例如,在混合性阿尔茨海默病和血管性痴呆症中,Angpt4基因的变异与疾病的发生发展相关[1]。在癌症中,Angpt4的表达水平与肿瘤的生长、转移和血管生成密切相关[2]。在先天性免疫中,Angpt4参与识别病原体和清除细菌,发挥重要的免疫防御作用[3]。在妊娠过程中,Angpt4的表达水平随妊娠时间的推移而变化,参与调节胎盘的血管生成和功能[4]。在视网膜中,Angpt4参与静脉成熟和液体排出,维持视网膜的正常功能[5]。在骨关节炎的治疗中,Angpt4的抑制可以促进软骨生成和抑制炎症反应[6]。在抑郁症中,Angpt4基因的变异与抑郁症状的发生相关[7]。在山羊的繁殖性状中,Angpt4基因的变异与产仔数相关[8]。此外,Angpt4基因的变异还与花生过敏和食物过敏的易感性相关[9]。在卵巢癌中,Angpt4的表达水平与患者的生存预后相关[10]。

综上所述,Angpt4是一种重要的血管生成因子,参与多种生物学过程,包括血管生成、血管稳定性、炎症反应、免疫调节、妊娠、视网膜功能、骨关节炎治疗、抑郁症、山羊繁殖性状和癌症等。Angpt4的研究有助于深入理解血管生成和免疫调节的分子机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Sillén, Anna, Brohede, Jesper, Lilius, Lena, Winblad, Bengt, Graff, Caroline. 2010. Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia. In Journal of human genetics, 55, 649-55. doi:10.1038/jhg.2010.79. https://pubmed.ncbi.nlm.nih.gov/20596041/
2. Zhou, Wenchao, Zhang, Qunfeng, Chen, Junling, Li, Yukun, Zou, Juan. 2024. Angiopoietin-4 expression and potential mechanisms in carcinogenesis: Current achievements and perspectives. In Clinical and experimental medicine, 24, 224. doi:10.1007/s10238-024-01449-2. https://pubmed.ncbi.nlm.nih.gov/39294405/
3. Zhou, Yang, Chen, Lu, Hao, Songtao, Cao, Xianke, Ni, Shousheng. 2024. Zebrafish ANGPT4, member of fibrinogen-related proteins, is an LTA-, LPS- and PGN-binding protein with a bacteriolytic activity. In Fish & shellfish immunology, 147, 109451. doi:10.1016/j.fsi.2024.109451. https://pubmed.ncbi.nlm.nih.gov/38360193/
4. Vaswani, Kanchan, Hum, Melissa Wen-Ching, Chan, Hsiu-Wen, Armitage, James A, Rice, Gregory E. 2013. The effect of gestational age on angiogenic gene expression in the rat placenta. In PloS one, 8, e83762. doi:10.1371/journal.pone.0083762. https://pubmed.ncbi.nlm.nih.gov/24391823/
5. Elamaa, Harri, Kihlström, Minna, Kapiainen, Emmi, Nätynki, Marjut, Eklund, Lauri. 2018. Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina. In eLife, 7, . doi:10.7554/eLife.37776. https://pubmed.ncbi.nlm.nih.gov/30444491/
6. Jeong, Se-Young, Kang, Mi-Lan, Park, Jeong-Won, Im, Gun-Il. 2019. Dual functional nanoparticles containing SOX duo and ANGPT4 shRNA for osteoarthritis treatment. In Journal of biomedical materials research. Part B, Applied biomaterials, 108, 234-242. doi:10.1002/jbm.b.34383. https://pubmed.ncbi.nlm.nih.gov/30957437/
7. Nho, Kwangsik, Ramanan, Vijay K, Horgusluoglu, Emrin, Niculescu, Alexander B, Saykin, Andrew J. . Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults. In Journal of Alzheimer's disease : JAD, 45, 1197-206. doi:10.3233/JAD-148009. https://pubmed.ncbi.nlm.nih.gov/25690665/
8. Sun, Xiaoyan, Niu, Qunhao, Jiang, Jing, Xu, Lingyang, Ren, Hangxing. 2023. Identifying Candidate Genes for Litter Size and Three Morphological Traits in Youzhou Dark Goats Based on Genome-Wide SNP Markers. In Genes, 14, . doi:10.3390/genes14061183. https://pubmed.ncbi.nlm.nih.gov/37372363/
9. Asai, Yuka, Eslami, Aida, van Ginkel, C Dorien, Clarke, Ann E, Daley, Denise. 2017. Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. In The Journal of allergy and clinical immunology, 141, 991-1001. doi:10.1016/j.jaci.2017.09.015. https://pubmed.ncbi.nlm.nih.gov/29030101/
10. Yuan, Dandan, Zhu, Hong, Wang, Ting, Zheng, Xin, Qu, Yanjun. 2023. Development and validation of an individualized gene expression-based signature to predict overall survival of patients with high-grade serous ovarian carcinoma. In European journal of medical research, 28, 465. doi:10.1186/s40001-023-01376-0. https://pubmed.ncbi.nlm.nih.gov/37884970/