Abhd11-KO 基因敲除小鼠

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产品名称

Abhd11-KO 基因敲除小鼠

产品编号

S-KO-18314

品系全称

C57BL/6JCya-Abhd11em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-68758-Abhd11-B6J-VA

品系状态

使用本品系发表的文献需注明: Abhd11-KO 基因敲除小鼠 mice (Strain S-KO-18314) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
abhydrolase domain containing 11
基因别称
1110054D16Rik,A630008N09Rik,Wbscr21
染色体号
Chr 5 (Mouse)
转录本 ID
NCBI: NM_145215 | Ensembl: ENSMUST00000046999
修饰方式
全身性基因敲除
靶向范围
Exon 3~6
敲除长度
~1.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1916008Mice homozygous for a null allele display resistance to high-fat diet induced obesity and multiple eye abnormalities resulting in blindness.
ABHD11,全称为Abhydrolase domain-containing protein 11,是一种在细胞中发挥多种生物学功能的蛋白质。该基因编码的蛋白质具有丝氨酸水解酶活性,主要定位于线粒体,能够合成内源性大麻素2-花生四烯酰甘油(2AG)。2AG是一种重要的信号分子,参与调节能量代谢、炎症反应和神经传递等生理过程。此外,ABHD11还与脂质代谢、细胞增殖、凋亡和肿瘤发生发展密切相关。

ABHD11在多种癌症中发挥着重要的生物学作用。在结直肠癌中,ABHD11的mRNA水平升高,与肿瘤的恶化和不良预后相关。研究发现,ABHD11通过与胰岛素样生长因子2 mRNA结合蛋白2(IGF2BP2)相互作用,增强FOX M1的稳定性,形成正反馈回路,从而抑制铁死亡,促进结直肠癌细胞的增殖和迁移[1]。在甲状腺乳头状癌中,ABHD11的mRNA水平同样升高,与淋巴转移和不良预后相关。ABHD11通过调节EPS15L1/EGFR信号通路,促进肿瘤细胞的增殖、迁移和侵袭能力[2]。

在宫颈癌中,ABHD11的mRNA水平升高,与肿瘤的恶化和不良预后相关。研究发现,ABHD11通过靶向调控miR-1254,加速宫颈癌细胞的增殖、侵袭和迁移[3]。此外,ABHD11还可以通过激活EGFR信号通路,防止FUS介导的ABHD11 mRNA降解,促进宫颈癌的进展[5]。在胃癌中,ABHD11的mRNA水平升高,与肿瘤的恶化和不良预后相关。ABHD11通过上调c-Myc促进胃癌细胞内的糖酵解,并加速胃癌进展[4]。此外,胃液中的ABHD11水平升高,与胃癌的早期诊断相关[9]。

此外,一项荟萃分析表明,ABHD11的表达与多种人类恶性肿瘤的预后密切相关。ABHD11的高表达与淋巴转移、肿瘤晚期和不良总生存期相关[6]。在甲状腺乳头状癌中,血清ABHD11的水平升高,与不良预后相关[7]。在宫颈癌中,ABHD11通过竞争性结合miR-330-5p并上调MARK2,促进肿瘤的发生发展[8]。

综上所述,ABHD11在多种癌症中发挥着重要的生物学作用,其高表达与肿瘤的恶化和不良预后相关。ABHD11可能成为癌症诊断和治疗的新靶点。

参考文献:
1. Bian, Yibo, Xu, Shufen, Gao, Zhishuang, Pu, Juan, Wang, Keming. 2024. m6A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21/IGF2BP2/ FOXM1 positive feedback loop. In Cancer letters, 596, 217004. doi:10.1016/j.canlet.2024.217004. https://pubmed.ncbi.nlm.nih.gov/38838765/
2. Lu, H, Zhu, C, Chen, Y, Chen, Q, Wei, Q. 2022. LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1/EGFR signaling pathway. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 24, 1124-1133. doi:10.1007/s12094-021-02753-z. https://pubmed.ncbi.nlm.nih.gov/35098448/
3. Zhu, Duanrong, Hao, Qun, Qian, Min, Hu, Yuli, Wu, Feifei. 2022. LncRNA ABHD11-AS1 Participates in the Progression of Cervical Carcinoma by Targeting miR-1254 and Is the Key to the Diagnosis and Treatment of Cervical Carcinoma in the Future. In Journal of healthcare engineering, 2022, 8387458. doi:10.1155/2022/8387458. https://pubmed.ncbi.nlm.nih.gov/35186240/
4. Feng, W, Lai, Y, Wang, J, Xu, P. . [Long non-coding RNA ABHD11-AS1 promotes glycolysis in gastric cancer cells to accelerate tumor progression]. In Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 43, 1485-1492. doi:10.12122/j.issn.1673-4254.2023.09.05. https://pubmed.ncbi.nlm.nih.gov/37814862/
5. Yang, Ting, Tian, Sijuan, Zhao, Juan, Zhao, Minyi, Yang, Xiaofeng. 2023. LncRNA ABHD11-AS1 activates EGFR signaling to promote cervical cancer progression by preventing FUS-mediated degradation of ABHD11 mRNA. In Cell cycle (Georgetown, Tex.), 22, 2538-2551. doi:10.1080/15384101.2023.2297591. https://pubmed.ncbi.nlm.nih.gov/38146687/
6. Lin, Guangyao, Ye, Tao, Wang, Jing. 2024. The association between long noncoding RNA ABHD11-AS1 and malignancy prognosis: a meta-analysis. In BMC cancer, 24, 1083. doi:10.1186/s12885-024-12866-7. https://pubmed.ncbi.nlm.nih.gov/39223500/
7. Hou, Sen, Zhuang, Yu-Ying, Lin, Qiu-Yu, Zhang, Laney, Lin, Cheng-He. 2021. Overexpression of serum lncRNA-ABHD11-AS1 as poor prognosis of patients with papillary thyroid carcinoma. In Experimental and molecular pathology, 121, 104658. doi:10.1016/j.yexmp.2021.104658. https://pubmed.ncbi.nlm.nih.gov/34102210/
8. Hou, Shunyu, Zhang, Xiaoqian, Yang, Jian. 2021. Long non-coding RNA ABHD11-AS1 facilitates the progression of cervical cancer by competitively binding to miR-330-5p and upregulating MARK2. In Experimental cell research, 410, 112929. doi:10.1016/j.yexcr.2021.112929. https://pubmed.ncbi.nlm.nih.gov/34793775/
9. Yang, Yunben, Shao, Yongfu, Zhu, Mengying, Sun, Yanke, Guo, Junming. 2015. Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker in the screening of gastric cancer. In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37, 1183-8. doi:10.1007/s13277-015-3903-3. https://pubmed.ncbi.nlm.nih.gov/26280398/