Adgrb3-KO 基因敲除小鼠

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产品名称

Adgrb3-KO 基因敲除小鼠

产品编号

S-KO-17232

品系全称

C57BL/6JCya-Adgrb3em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-210933-Adgrb3-B6J-VB

品系状态

使用本品系发表的文献需注明: Adgrb3-KO 基因敲除小鼠 mice (Strain S-KO-17232) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
adhesion G protein-coupled receptor B3
基因别称
A830096D10Rik,Bai3
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_175642 | Ensembl: ENSMUST00000151309
修饰方式
全身性基因敲除
靶向范围
Exon 8~9
敲除长度
~1.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2441837Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology.
ADGRB3(也称为BAI3)是一种属于粘附G蛋白偶联受体(adhesion GPCRs)亚家族的基因,其编码的蛋白在多种生物学过程中发挥重要作用,包括中枢神经系统的轴突导向、髓鞘形成和突触形成等[2]。ADGRB3基因突变与多种神经发育障碍有关,包括智力障碍、共济失调和行为障碍等[2]。

最近的研究表明,ADGRB3基因在多种癌症中发挥重要作用。例如,在结直肠癌中,ADGRB3基因表达下调,与癌症的发生和发展相关[1]。此外,ADGRB3基因的遗传变异与焦虑气质有关[3]。在慢性鼻窦炎伴鼻息肉(CRSwNP)中,ADGRB3基因表达上调,与疾病的进展相关[4]。此外,ADGRB3基因的遗传变异与羊对胃肠道线虫(GIN)的抵抗性或易感性有关[5]。在脑肿瘤中,ADGRB3基因表达上调,与患者的不良预后相关[6]。在奶牛中,ADGRB3基因与乳房形状有关[7]。在胎儿过度生长中,ADGRB3基因甲基化水平升高,与出生体重相关[8]。

综上所述,ADGRB3基因在多种生物学过程中发挥重要作用,包括中枢神经系统的发育、癌症的发生和发展、寄生虫感染、情绪气质、慢性鼻窦炎、脑肿瘤和奶牛的乳房形状等。ADGRB3基因的遗传变异和表达水平可能与多种疾病的易感性和预后相关。因此,深入研究ADGRB3基因的功能和调控机制,对于疾病的治疗和预防具有重要意义。

参考文献:
1. Zhang, Yu, Luo, Jia, Liu, Zhe, Wang, Lei, Song, Xinqiang. . Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas. In Bioscience reports, 41, . doi:10.1042/BSR20211280. https://pubmed.ncbi.nlm.nih.gov/34308980/
2. Scuderi, Carmela, Saccuzzo, Lucia, Vinci, Mirella, Romano, Corrado, Fichera, Marco. 2019. Biallelic intragenic duplication in ADGRB3 (BAI3) gene associated with intellectual disability, cerebellar atrophy, and behavioral disorder. In European journal of human genetics : EJHG, 27, 594-602. doi:10.1038/s41431-018-0321-1. https://pubmed.ncbi.nlm.nih.gov/30659260/
3. Gonda, Xenia, Eszlari, Nora, Torok, Dora, Juhasz, Gabriella, Bagdy, Gyorgy. 2021. Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene. In Translational psychiatry, 11, 337. doi:10.1038/s41398-021-01436-1. https://pubmed.ncbi.nlm.nih.gov/34075027/
4. Wang, Yakun, Li, Zufei, Lu, Jun. 2024. Single-cell RNA sequencing reveals the epithelial cell, fibroblast, and key gene alterations in chronic rhinosinusitis with nasal polyps. In Scientific reports, 14, 2270. doi:10.1038/s41598-024-52341-8. https://pubmed.ncbi.nlm.nih.gov/38280891/
5. Becker, Gabrielle M, Burke, Joan M, Lewis, Ronald M, Notter, David R, Murdoch, Brenda M. 2022. Variants Within Genes EDIL3 and ADGRB3 are Associated With Divergent Fecal Egg Counts in Katahdin Sheep at Weaning. In Frontiers in genetics, 13, 817319. doi:10.3389/fgene.2022.817319. https://pubmed.ncbi.nlm.nih.gov/35360858/
6. Namiot, E D, Zembatov, G M, Tregub, P P. 2024. Insights into brain tumor diagnosis: exploring in situ hybridization techniques. In Frontiers in neurology, 15, 1393572. doi:10.3389/fneur.2024.1393572. https://pubmed.ncbi.nlm.nih.gov/39022728/
7. Nazar, Mudasir, Abdalla, Ismail Mohamed, Chen, Zhi, Yang, Zhangping, Lu, Xubin. 2022. Genome-Wide Association Study for Udder Conformation Traits in Chinese Holstein Cattle. In Animals : an open access journal from MDPI, 12, . doi:10.3390/ani12192542. https://pubmed.ncbi.nlm.nih.gov/36230283/
8. Yang, Meng-Nan, Huang, Rong, Zheng, Tao, Li, Jiong, Luo, Zhong-Cheng. 2022. Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors. In Clinical epigenetics, 14, 192. doi:10.1186/s13148-022-01412-6. https://pubmed.ncbi.nlm.nih.gov/36585686/