Lgals3-KO 基因敲除小鼠

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产品名称

Lgals3-KO 基因敲除小鼠

产品编号

S-KO-16923

品系全称

C57BL/6JCya-Lgals3em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-16854-Lgals3-B6J-VA

品系状态

使用本品系发表的文献需注明: Lgals3-KO 基因敲除小鼠 mice (Strain S-KO-16923) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
lectin, galactose binding, soluble 3
基因别称
GBP,L-34,Mac-2,gal3
染色体号
Chr 14 (Mouse)
转录本 ID
NCBI: NM_010705 | Ensembl: ENSMUST00000142734
修饰方式
全身性基因敲除
靶向范围
Exon 3~4
敲除长度
~2.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96778Homozygotes for a null allele show susceptibility to S. pneumoniae infection, resistance to renal fibrosis, defects in chondrocyte differentiation, and impaired macrophage activation. Homozygotes for another null allele show altered peritoneal inflammation, and susceptibility to T. gondii infection. Homozygosity for a glycan-binding deficient mutation leads to increased vertebral bone density in aged female mice.
LGALS3,也称为Galectin-3,是一种重要的β-半乳糖苷结合凝集素。它是一种可溶性蛋白,在多种细胞类型中表达,包括巨噬细胞、T细胞、B细胞和内皮细胞。LGALS3在多种生物学过程中发挥重要作用,包括细胞粘附、细胞迁移、细胞凋亡和免疫调节。此外,LGALS3还参与调节细胞内的信号通路,如Wnt/β-catenin信号通路。

LGALS3在多种疾病中发挥重要作用,包括类风湿性关节炎、肝细胞癌、结直肠癌、神经退行性疾病和心肌病。在类风湿性关节炎中,LGALS3基因的某些多态性与疾病风险相关[1]。在肝细胞癌中,LGALS3基因的表达水平与疾病的进展相关,并可能作为生物标志物[2]。在结直肠癌中,LGALS3基因的多态性与肿瘤大小和粘液成分相关[3]。在神经退行性疾病中,LGALS3基因的表达水平与疾病的进展相关,并可能作为治疗靶点[4,5,6]。在心肌病中,LGALS3基因的多态性与疾病易感性相关[7]。

综上所述,LGALS3是一种重要的蛋白质,在多种生物学过程中发挥重要作用,并参与多种疾病的发病机制。LGALS3的研究有助于深入理解这些疾病的发病机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Xu, Wang-Dong, Wu, Qian, He, Yan-Wei, Zhou, Jie, Liu, Xiao-Yan. 2021. Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis. In Cellular immunology, 368, 104419. doi:10.1016/j.cellimm.2021.104419. https://pubmed.ncbi.nlm.nih.gov/34371260/
2. Dong, Jianming, Zhang, Rongzheng, Xia, Yan, Cao, Xinyang, Zhang, Shuyun. 2023. The necroptosis related gene LGALS3 can be used as a biomarker for the adverse progression from chronic HBV infection to HCC. In Frontiers in immunology, 14, 1142319. doi:10.3389/fimmu.2023.1142319. https://pubmed.ncbi.nlm.nih.gov/37180150/
3. Korkmaz, Gurbet, Horozoglu, Cem, Arıkan, Soykan, Ergen, Arzu, Yaylım, İlhan. 2016. LGALS3 and AXIN1 gene variants playing role in the Wnt/ β-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer. In Bosnian journal of basic medical sciences, 16, 108-13. doi:10.17305/bjbms.2016.721. https://pubmed.ncbi.nlm.nih.gov/26894286/
4. Margeta, Milica A, Yin, Zhuoran, Madore, Charlotte, Chen, Dong Feng, Butovsky, Oleg. 2022. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. In Immunity, 55, 1627-1644.e7. doi:10.1016/j.immuni.2022.07.014. https://pubmed.ncbi.nlm.nih.gov/35977543/
5. Yin, Zhuoran, Rosenzweig, Neta, Kleemann, Kilian L, Holtzman, David M, Butovsky, Oleg. 2023. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. In Nature immunology, 24, 1839-1853. doi:10.1038/s41590-023-01627-6. https://pubmed.ncbi.nlm.nih.gov/37749326/
6. Boza-Serrano, Antonio, Ruiz, Rocío, Sanchez-Varo, Raquel, Venero, Jose Luis, Deierborg, Tomas. 2019. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. In Acta neuropathologica, 138, 251-273. doi:10.1007/s00401-019-02013-z. https://pubmed.ncbi.nlm.nih.gov/31006066/
7. Zhang, Yuhui, Wang, Yunhong, Zhai, Mei, Zhou, Qiong, Zhang, Jian. 2017. Influence of LGALS3 gene polymorphisms on susceptibility and prognosis of dilated cardiomyopathy in a Northern Han Chinese population. In Gene, 642, 293-298. doi:10.1016/j.gene.2017.11.026. https://pubmed.ncbi.nlm.nih.gov/29129812/