Pdhx-KO 基因敲除小鼠

1. Jiang, Zetan, Xiong, Nanchi, Yan, Ronghui, Jia, Weidong, Zhang, Huafeng. . PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression. In Protein & cell, 16, 49-63. doi:10.1093/procel/pwae052. https://pubmed.ncbi.nlm.nih.gov/39311688/

2. Jiang, Runmin, Sun, Ying, Li, Yan, Lei, Jie, Jiang, Tao. 2023. Cuproptosis-related gene PDHX and heat stress-related HSPD1 as potential key drivers associated with cell stemness, aberrant metabolism and immunosuppression in esophageal carcinoma. In International immunopharmacology, 117, 109942. doi:10.1016/j.intimp.2023.109942. https://pubmed.ncbi.nlm.nih.gov/36889194/

3. Hassan, Anhar. 2023. Episodic Ataxias: Primary and Secondary Etiologies, Treatment, and Classification Approaches. In Tremor and other hyperkinetic movements (New York, N.Y.), 13, 9. doi:10.5334/tohm.747. https://pubmed.ncbi.nlm.nih.gov/37008993/

4. Miné, Manuèle, Brivet, Michèle, Schiff, Manuel, Chuzhanova, Nadia, Marsac, Cécile. 2006. A novel gross deletion caused by non-homologous recombination of the PDHX gene in a patient with pyruvate dehydrogenase deficiency. In Molecular genetics and metabolism, 89, 106-10. doi:. https://pubmed.ncbi.nlm.nih.gov/16843025/

5. Huang, Xing, Gan, Guangming, Wang, Xiaoxiao, Xu, Ting, Xie, Wei. 2019. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. In Autophagy, 15, 1258-1279. doi:10.1080/15548627.2019.1580105. https://pubmed.ncbi.nlm.nih.gov/30786811/

6. Eastlack, Steven C, Dong, Shengli, Ivan, Cristina, Alahari, Suresh K. 2018. Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer. In Molecular cancer, 17, 100. doi:10.1186/s12943-018-0851-8. https://pubmed.ncbi.nlm.nih.gov/30012170/

7. Inoue, Jun, Kishikawa, Masahiro, Tsuda, Hitoshi, Asakage, Takahiro, Inazawa, Johji. 2021. Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma. In Cancer science, 112, 2792-2802. doi:10.1111/cas.14938. https://pubmed.ncbi.nlm.nih.gov/33964039/

8. Pinheiro, Ana, Silva, Maria João, Pavlu-Pereira, Hana, Tavares de Almeida, Isabel, Rivera, Isabel. 2016. Complex genetic findings in a female patient with pyruvate dehydrogenase complex deficiency: Null mutations in the PDHX gene associated with unusual expression of the testis-specific PDHA2 gene in her somatic cells. In Gene, 591, 417-24. doi:10.1016/j.gene.2016.06.041. https://pubmed.ncbi.nlm.nih.gov/27343776/