C1qc-KO 基因敲除小鼠

下单100%中奖,最高可得千元京东卡
复苏/繁育服务
产品名称

C1qc-KO 基因敲除小鼠

产品编号

S-KO-15962

品系全称

C57BL/6JCya-C1qcem1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-12262-C1qc-B6J-VB

品系状态

使用本品系发表的文献需注明: C1qc-KO 基因敲除小鼠 mice (Strain S-KO-15962) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
complement component 1, q subcomponent, C chain
基因别称
Adib,C1qg,Ciqc
染色体号
Chr 4 (Mouse)
转录本 ID
NCBI: NM_007574.2 | Ensembl: ENSMUST00000046332
修饰方式
全身性基因敲除
靶向范围
Exon 3
敲除长度
~2.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
C1qc,全称为补体C1q C链,是补体系统的重要组成部分。补体系统是人体免疫系统的一部分,负责识别并清除病原体、受损细胞和细胞碎片。C1q是补体系统的起始成分,由C1q A、B、C三个亚基组成,其中C1q C链是其中一个亚基。C1q在免疫应答中发挥重要作用,可以识别并结合抗原抗体复合物、凋亡细胞和病原体表面的特定分子,从而激活补体级联反应,导致病原体的溶解、炎症反应的启动以及免疫细胞的招募。C1q还参与调节免疫细胞的功能,如巨噬细胞的吞噬作用和T细胞的活化。此外,C1q还与多种疾病的发生发展有关,包括动脉粥样硬化、癌症和自身免疫性疾病。

C1qc在动脉粥样硬化中发挥重要作用。一项研究通过单细胞RNA测序和全转录组分析,确定了C1Q相关的枢纽基因,并建立了机器学习模型来诊断和区分动脉粥样硬化的类型。研究发现,C1QA和C1QC两个基因在动脉粥样硬化斑块中表达上调,并且与缺血性中风的发生风险相关[1]。此外,C1qc还参与调节肿瘤微环境,影响肿瘤的发生发展和治疗。例如,C1QC和SPP1基因在肿瘤相关巨噬细胞中表达上调,可以区分宫颈癌患者的不同预后和免疫细胞浸润情况[2]。在非小细胞肺癌中,C1QC基因在不同性别的肿瘤相关巨噬细胞中表达存在差异,男性患者中C1QC表达上调,可能成为免疫治疗的理想靶点[3]。在乳腺癌中,C1QC基因在肿瘤-脂肪微环境中表达上调,与肿瘤进展和不良预后相关[4]。在肾脏透明细胞癌中,C1QC基因表达上调与肿瘤分期、转移和不良预后相关,并且与肿瘤浸润免疫细胞有关[5]。此外,C1qc还与宫颈癌、骨关节炎、弥漫性大B细胞淋巴瘤和草鱼病毒感染等疾病的发生发展相关[6,7,8,9,10]。

综上所述,C1qc作为一种重要的补体蛋白,在免疫应答和疾病发生发展中发挥重要作用。C1qc的表达和功能与动脉粥样硬化、癌症、自身免疫性疾病等多种疾病的发生发展密切相关。深入研究C1qc的功能和机制,有助于开发新的治疗策略和诊断方法,为相关疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Cui, Hong-Kai, Tang, Chao-Jie, Gao, Yu, Zhang, Jian, Li, Yong-Dong. 2023. An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis. In Frontiers in immunology, 14, 1289223. doi:10.3389/fimmu.2023.1289223. https://pubmed.ncbi.nlm.nih.gov/38179058/
2. Li, Xiong, Zhang, Qinghua, Chen, Gang, Luo, Danfeng. 2021. Multi-Omics Analysis Showed the Clinical Value of Gene Signatures of C1QC+ and SPP1+ TAMs in Cervical Cancer. In Frontiers in immunology, 12, 694801. doi:10.3389/fimmu.2021.694801. https://pubmed.ncbi.nlm.nih.gov/34295336/
3. Yang, Qi, Zhang, Hongman, Wei, Ting, Luo, Peng, Zhang, Jian. 2021. Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes. In Frontiers in immunology, 12, 756722. doi:10.3389/fimmu.2021.756722. https://pubmed.ncbi.nlm.nih.gov/34804043/
4. Liu, Zhou, Gao, Zhijie, Li, Bei, Sun, Shengrong, Wu, Qi. 2022. Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression. In Oncoimmunology, 11, 2085432. doi:10.1080/2162402X.2022.2085432. https://pubmed.ncbi.nlm.nih.gov/35712121/
5. Patra, Pratap Kumar, Banday, Aaqib Zaffar, Nisar, Rahila, Reddy, Pakkiresh, Bhattarai, Dharmagat. 2022. Persistent skin ulceration - First manifestation of lupus in a child with novel homozygous deletion in C1QC gene. In The Australasian journal of dermatology, 64, e107-e108. doi:10.1111/ajd.13955. https://pubmed.ncbi.nlm.nih.gov/36416474/
6. Yao, Wentao, Liu, Hanyuan, Xu, Feng, Yang, Chendi, Zong, Yang. 2023. C1QC is a prognostic biomarker with immune-related value in kidney renal clear cell carcinoma. In Frontiers in genetics, 14, 1109991. doi:10.3389/fgene.2023.1109991. https://pubmed.ncbi.nlm.nih.gov/36992705/
7. Qiu, Junjun, Qu, Xinyu, Wang, Yumeng, Wang, Li, Hua, Keqin. 2023. Single-Cell Landscape Highlights Heterogenous Microenvironment, Novel Immune Reaction Patterns, Potential Biomarkers and Unique Therapeutic Strategies of Cervical Squamous Carcinoma, Human Papillomavirus-Associated (HPVA) and Non-HPVA Adenocarcinoma. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2204951. doi:10.1002/advs.202204951. https://pubmed.ncbi.nlm.nih.gov/36725337/
8. Zeng, Junfeng, Jiang, Xinhao, Jiang, Mo, Cao, Yuexia, Jiang, Yi. 2023. Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers. In Scientific reports, 13, 22894. doi:10.1038/s41598-023-48446-1. https://pubmed.ncbi.nlm.nih.gov/38129488/
9. Gao, Guangcan, Sun, Naitong, Zhang, Yaping, Tang, Yunlong, Shi, Wenyu. 2024. Single-cell sequencing in diffuse large B-cell lymphoma: C1qC is a potential tumor-promoting factor. In International immunopharmacology, 143, 113319. doi:10.1016/j.intimp.2024.113319. https://pubmed.ncbi.nlm.nih.gov/39388888/
10. Yang, Le, Wang, Chong, Huang, Yuhong, Xiao, Tiaoyi, Liu, Qiaolin. 2024. Identification of the C1qDC gene family in grass carp (Ctenopharyngodon idellus) and the response of C1qA, C1qB, and C1qC to GCRV infection in vivo and in vitro. In Fish & shellfish immunology, 148, 109477. doi:10.1016/j.fsi.2024.109477. https://pubmed.ncbi.nlm.nih.gov/38447782/