1. Rab30在果蝇胚胎发育过程中参与JNK信号通路调节的膜转运过程,影响形态发生过程[1]。
2. Rab30主要定位在高尔基体,参与调节与高尔基体相关的膜转运过程,维持高尔基体的形态完整性[2]。
3. Rab30在肝脏再生过程中的表达水平上调,可能与肝脏再生过程中细胞内物质的转运和代谢有关[3]。
4. Rab30在神经母细胞瘤中的表达水平与患者的预后相关,Rab30的表达上调可能与神经母细胞瘤的发生和发展有关[4]。
参考文献:
1. Thomas, Chloe, Rousset, Raphaël, Noselli, Stéphane. 2009. JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30. In Developmental biology, 331, 250-60. doi:10.1016/j.ydbio.2009.05.001. https://pubmed.ncbi.nlm.nih.gov/19427848/
2. Kelly, Eoin E, Giordano, Francesca, Horgan, Conor P, Raposo, Graça, McCaffrey, Mary W. 2011. Rab30 is required for the morphological integrity of the Golgi apparatus. In Biology of the cell, 104, 84-101. doi:10.1111/boc.201100080. https://pubmed.ncbi.nlm.nih.gov/22188167/
3. Chiba, Mitsuru, Murata, Soichiro, Myronovych, Andriy, Yasue, Hiroshi, Ohkohchi, Nobuhiro. 2011. Elevation and characteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse. In International journal of molecular medicine, 27, 567-74. doi:10.3892/ijmm.2011.614. https://pubmed.ncbi.nlm.nih.gov/21308349/
4. Bae, Joon Seol, Lee, Ji Won, Joung, Je-Gun, Koo, Hong Hoe, Sung, Ki Woong. 2022. Clinical significance of germline telomere length and associated genetic factors in patients with neuroblastoma. In Scientific reports, 12, 12954. doi:10.1038/s41598-022-17246-4. https://pubmed.ncbi.nlm.nih.gov/35902621/