Dcstamp-KO 基因敲除小鼠

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产品名称

Dcstamp-KO 基因敲除小鼠

产品编号

S-KO-14737

品系全称

C57BL/6JCya-Dcstampem1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-75766-Dcstamp-B6J-VA

品系状态

使用本品系发表的文献需注明: Dcstamp-KO 基因敲除小鼠 mice (Strain S-KO-14737) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
dendrocyte expressed seven transmembrane protein
基因别称
4833414I07Rik,DC-STAMP,FIND,Tm7sf4,mDC-STAMP
染色体号
Chr 15 (Mouse)
转录本 ID
NCBI: NM_029422 | Ensembl: ENSMUST00000022913
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~6.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1923016Targeted disruption of this gene causes complete loss of osteoclast and macrophage cell fusion and leads to reduced bone-resorbing activity and mild osteopetrosis.

发表文献

Preprint
2023-08-30
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
1
DC-STAMP,也称为TM7SF4,是一种在破骨细胞分化中发挥关键作用的跨膜蛋白。破骨细胞是负责骨吸收的细胞,其分化过程受多种信号通路的调控,包括RANKL/RANK信号通路、NF-κB信号通路、NFATc1信号通路等。DC-STAMP在破骨细胞融合过程中发挥重要作用,其表达水平与破骨细胞的形成和功能密切相关。

DC-STAMP在多种骨代谢疾病中发挥重要作用,包括Paget病、骨质疏松症、类风湿性关节炎等。Paget病是一种以骨代谢异常为特征的代谢性骨病,其特点是骨重塑活跃,骨吸收和骨形成均增加。研究发现,DC-STAMP基因突变与Paget病的发生发展密切相关[5]。骨质疏松症是一种以骨量减少和骨微结构破坏为特征的骨骼疾病,其特点是骨强度降低,易发生骨折。研究发现,DC-STAMP表达水平与骨质疏松症的发生发展相关[1,3,6]。类风湿性关节炎是一种以慢性关节炎症为特征的自身免疫性疾病,其特点是关节软骨和骨组织的破坏。研究发现,DC-STAMP表达水平与类风湿性关节炎的发生发展相关[2,4,7]。

DC-STAMP在肿瘤中也发挥重要作用,包括甲状腺癌、骨肉瘤等。甲状腺癌是一种常见的内分泌系统恶性肿瘤,其特点是甲状腺组织的异常增生和侵袭。研究发现,DC-STAMP在甲状腺癌中表达上调,与不良预后相关[8]。骨肉瘤是一种常见的骨组织恶性肿瘤,其特点是骨组织的异常增生和侵袭。研究发现,DC-STAMP在骨肉瘤中表达上调,与肿瘤的发生发展相关[1,3,6]。

综上所述,DC-STAMP在多种骨代谢疾病和肿瘤中发挥重要作用,参与调控骨吸收和骨形成、炎症反应、细胞增殖和侵袭等生物学过程。DC-STAMP的研究有助于深入理解骨代谢和肿瘤发生发展的机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Staubitz-Vernazza, Julia I, Müller, Celine, Heymans, Antonia, Musholt, Thomas J, Hartmann, Nils. . Gene Expression Profiles of AHNAK2, DCSTAMP, FN1, and TERT Correlate With Mutational Status and Recurrence in Papillary Thyroid Carcinoma. In Genes, chromosomes & cancer, 63, e23256. doi:10.1002/gcc.23256. https://pubmed.ncbi.nlm.nih.gov/39193983/
2. Zeng, Xiang-zhou, He, Long-gang, Wang, Song, Li, Xiao-juan, Liu, Shu-wen. 2015. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression. In Acta pharmacologica Sinica, 37, 255-63. doi:10.1038/aps.2015.85. https://pubmed.ncbi.nlm.nih.gov/26592521/
3. Zeng, Xiang-Zhou, Zhang, Yue-Yang, Yang, Qin, Liu, Shu-Wen, Li, Xiao-Juan. 2019. Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway. In Acta pharmacologica Sinica, 41, 229-236. doi:10.1038/s41401-019-0289-6. https://pubmed.ncbi.nlm.nih.gov/31431733/
4. . 2020. Expression of Concern. In Cellular microbiology, 22, e13259. doi:10.1111/cmi.13259. https://pubmed.ncbi.nlm.nih.gov/33001519/
5. Sultana, M A, Pavlos, N J, Ward, Lynley, Walsh, J P, Rea, S L. 2019. Targeted sequencing of DCSTAMP in familial Paget's disease of bone. In Bone reports, 10, 100198. doi:10.1016/j.bonr.2019.100198. https://pubmed.ncbi.nlm.nih.gov/30886882/
6. Anuj, Anuj, Reuven, Nina, Roberts, Stefan G E, Elson, Ari. 2023. BASP1 down-regulates RANKL-induced osteoclastogenesis. In Experimental cell research, 431, 113758. doi:10.1016/j.yexcr.2023.113758. https://pubmed.ncbi.nlm.nih.gov/37619639/
7. Mullin, Benjamin H, Zhu, Kun, Brown, Suzanne J, Walsh, John P, Wilson, Scott G. 2019. Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget's disease of bone. In Scientific reports, 9, 1052. doi:10.1038/s41598-018-37609-0. https://pubmed.ncbi.nlm.nih.gov/30705363/
8. Lee, Jie-Jen, Hsu, Yi-Chiung, Huang, Wen-Chien, Cheng, Shih-Ping. 2023. Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer. In Endocrine, 81, 513-520. doi:10.1007/s12020-023-03364-0. https://pubmed.ncbi.nlm.nih.gov/37058220/

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