MGI:1920537Mice homozygous for a knock-out allele exhibit male infertility, oligozoospermia, asthenozoospermia, and defects in sperm flagellum formation.
Cabcoco1,全称为ciliary-associated calcium-binding coiled-coil protein 1,是一种钙结合蛋白,属于卷曲螺旋家族。该蛋白在精子的鞭毛中定位,并参与了鞭毛的形成和运动。Cabcoco1在哺乳动物的生殖过程中发挥着重要作用,尤其是在精子发生和成熟过程中。研究表明,Cabcoco1的异常表达或功能障碍可能与男性不育相关。
1. Kawashima, Akihiro, Kigoshi, Takumi, Katoh, Yuki, Matsuda, Manabu, Okamura, Naomichi. 2016. CABCOCO1, a novel coiled-coil protein With calcium-binding activity, is localized in the sperm flagellum. In Molecular reproduction and development, 83, 912-926. doi:10.1002/mrd.22639. https://pubmed.ncbi.nlm.nih.gov/26990073/