Mboat2-KO 基因敲除小鼠

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产品名称

Mboat2-KO 基因敲除小鼠

产品编号

S-KO-12170

品系全称

C57BL/6JCya-Mboat2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-67216-Mboat2-B6J-VA

品系状态

使用本品系发表的文献需注明: Mboat2-KO 基因敲除小鼠 mice (Strain S-KO-12170) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
membrane bound O-acyltransferase domain containing 2
基因别称
2810049G06Rik,LPCAT4,Moact2,Oact2
染色体号
Chr 12 (Mouse)
转录本 ID
NCBI: NM_026037 | Ensembl: ENSMUST00000110942
修饰方式
全身性基因敲除
靶向范围
Exon 11
敲除长度
~0.9 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
Mboat2,全称为membrane-bound O-acyltransferase domain-containing 2,是一种编码膜结合O-酰基转移酶结构域的基因。该基因编码的蛋白质具有酰基转移酶活性,参与磷脂的代谢过程。Mboat2基因的表达和功能在多种生物学过程中发挥重要作用,包括细胞周期、细胞信号传导、免疫反应和肿瘤发生发展等。

在肿瘤发生发展中,Mboat2基因的表达水平与肿瘤的预后和免疫浸润密切相关。例如,研究发现,在子宫内膜癌中,Mboat2基因的表达水平与患者的预后不良相关,并且与免疫浸润细胞的数量和功能有关[1]。在胰腺癌中,Mboat2基因的表达水平与KRAS基因的激活和CD8+ T细胞浸润减少相关,提示Mboat2基因可能是胰腺癌的潜在原癌基因,并且与肿瘤免疫微环境密切相关[2]。此外,Mboat2基因的表达水平还与肝细胞癌、乳腺癌等肿瘤的预后相关[3]。

除了在肿瘤发生发展中的作用,Mboat2基因还参与其他生物学过程。例如,研究发现,Mboat2基因的表达水平与高密度脂蛋白胆固醇(HDL-C)的水平变化相关,提示Mboat2基因可能参与脂质代谢过程[4]。此外,Mboat2基因的表达水平还与实验性自身免疫性脑脊髓炎(EAE)的发病机制相关,提示Mboat2基因可能参与神经免疫调节过程[5]。

综上所述,Mboat2基因是一种重要的基因,参与多种生物学过程,包括肿瘤发生发展、脂质代谢和神经免疫调节等。Mboat2基因的表达水平与肿瘤的预后和免疫浸润密切相关,提示Mboat2基因可能成为肿瘤治疗和免疫治疗的潜在靶点。此外,Mboat2基因的研究还有助于深入理解磷脂代谢、脂质代谢和神经免疫调节的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略[6][7][8][9][10]。

参考文献:
1. Huang, Huaqing, Cai, Xintong, Lin, Jiexiang, Liu, Bin, Lin, Jie. 2023. A novel five-gene metabolism-related risk signature for predicting prognosis and immune infiltration in endometrial cancer: A TCGA data mining. In Computers in biology and medicine, 155, 106632. doi:10.1016/j.compbiomed.2023.106632. https://pubmed.ncbi.nlm.nih.gov/36805217/
2. Li, Zhenchong, Zhuang, Hongkai, Chen, Xinming, Zhang, Chuanzhao, Hou, Baohua. 2022. Identification of MBOAT2 as an Unfavorable Biomarker Correlated with KRAS Activation and Reduced CD8+ T-Cell Infiltration in Pancreatic Cancer. In Journal of oncology, 2022, 4269733. doi:10.1155/2022/4269733. https://pubmed.ncbi.nlm.nih.gov/35571489/
3. Wang, Qingqing, Zhou, Shuning, Hu, Xinyi, Gao, Yu, Li, Shujing. 2023. Circadian Genes MBOAT2/CDA/LPCAT2/B4GALT5 in the Metabolic Pathway Serve as New Biomarkers of PACA Prognosis and Immune Infiltration. In Life (Basel, Switzerland), 13, . doi:10.3390/life13051116. https://pubmed.ncbi.nlm.nih.gov/37240761/
4. Feitosa, Mary F, Lunetta, Kathryn L, Wang, Lihua, Murabito, Joanne M, Province, Michael A. 2020. Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. In Atherosclerosis, 297, 102-110. doi:10.1016/j.atherosclerosis.2020.02.005. https://pubmed.ncbi.nlm.nih.gov/32109663/
5. Zhu, Lihui, Liao, Rongrong, Huang, Jiwen, Yan, Huaxiang, Yang, Changsuo. 2022. Lactobacillus salivarius SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens. In Cells, 11, . doi:10.3390/cells11244133. https://pubmed.ncbi.nlm.nih.gov/36552896/
6. Zeng, Xu, Zhang, Kexue, Liang, Ming, Mehmood, Arshad, Zhang, Hongtian. 2024. NAD+ affects differentially expressed genes-MBOAT2-SLC25A21-SOX6 in experimental autoimmune encephalomyelitis model. In The International journal of neuroscience, , 1-8. doi:10.1080/00207454.2024.2313022. https://pubmed.ncbi.nlm.nih.gov/38315116/
7. Wang, Hongdong, Guo, Hui, Sun, Jiaao, Wang, Yuefeng. 2023. Multi-omics analyses based on genes associated with oxidative stress and phospholipid metabolism revealed the intrinsic molecular characteristics of pancreatic cancer. In Scientific reports, 13, 13564. doi:10.1038/s41598-023-40560-4. https://pubmed.ncbi.nlm.nih.gov/37604837/
8. Ståhl, Ulf, Stålberg, Kjell, Stymne, Sten, Ronne, Hans. 2007. A family of eukaryotic lysophospholipid acyltransferases with broad specificity. In FEBS letters, 582, 305-9. doi:. https://pubmed.ncbi.nlm.nih.gov/18154737/
9. Mehmood, Arshad, Song, Shuang, Du, Xiaochen, Guo, Li, Li, Bin. 2023. mRNA expression profile reveals differentially expressed genes in splenocytes of experimental autoimmune encephalomyelitis model. In International journal of experimental pathology, 104, 247-257. doi:10.1111/iep.12488. https://pubmed.ncbi.nlm.nih.gov/37427716/
10. Xie, Lin-Ying, Huang, Han-Ying, Fang, Tian, Tan, Ye-Hui, Zeng, Lei. 2022. A Prognostic Survival Model of Pancreatic Adenocarcinoma Based on Metabolism-Related Gene Expression. In Frontiers in genetics, 13, 804190. doi:10.3389/fgene.2022.804190. https://pubmed.ncbi.nlm.nih.gov/35664305/