P3h4-KO 基因敲除小鼠

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产品名称

P3h4-KO 基因敲除小鼠

产品编号

S-KO-11574

品系全称

C57BL/6JCya-P3h4em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-66180-P3h4-B6J-VA

品系状态

使用本品系发表的文献需注明: P3h4-KO 基因敲除小鼠 mice (Strain S-KO-11574) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
prolyl 3-hydroxylase family member 4 (non-enzymatic)
基因别称
1110036O03Rik,Leprel4,Sc65
染色体号
Chr 11 (Mouse)
转录本 ID
NCBI: NM_176830 | Ensembl: ENSMUST00000066489
修饰方式
全身性基因敲除
靶向范围
Exon 5~8
敲除长度
~4.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1913430Mice homozygous for a knock-out allele exhibit decreased trabecular volume, compact bone thickness, skin tensile strength and muscle below the hypodermis with decreased cutaneous collagen fiber density.
P3H4,全称为Prolyl 3-hydroxylase family member 4,是一种在人类癌症发展中具有重要作用的基因。P3H4的表达水平与多种癌症的预后相关,例如膀胱癌和肺腺癌。研究表明,P3H4在膀胱癌组织中表达上调,且高表达水平与不良预后相关。此外,P3H4的表达与膀胱癌的多个临床病理特征相关,包括年龄、种族、组织学分级、肿瘤组织学亚型和AJCC分期等。在肺腺癌中,P3H4的表达同样上调,且与肿瘤的侵袭和转移相关。P3H4的过表达可以促进肺腺癌细胞的增殖和侵袭,并与EGFR相互作用,调节代谢物质。因此,P3H4在多种癌症中发挥重要作用,可能成为新的治疗靶点和预后标志物[1,2,3,4,5,6,7,8,9,10]。

参考文献:
1. Zhang, Junjie, Dong, Yang, Shi, Zhenduo, Han, Conghui, Hao, Lin. 2022. P3H4 and PLOD1 expression associates with poor prognosis in bladder cancer. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 24, 1524-1532. doi:10.1007/s12094-022-02791-1. https://pubmed.ncbi.nlm.nih.gov/35149972/
2. Fang, Chen, Liang, Yingkuan, Huang, Yong, Jiang, Wei, Feng, Yu. 2022. P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR. In Cancers, 14, . doi:10.3390/cancers14133243. https://pubmed.ncbi.nlm.nih.gov/35805016/
3. Hao, Lin, Pang, Kun, Pang, Hui, Shi, Zhenduo, Han, Conghui. 2020. Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer. In Aging, 12, 2156-2168. doi:10.18632/aging.102732. https://pubmed.ncbi.nlm.nih.gov/32018225/
4. Jin, Xiangfeng, Zhou, Haiqing, Song, Jianfang, Luo, Yiren, Jiang, Haiping. 2021. P3H4 Overexpression Serves as a Prognostic Factor in Lung Adenocarcinoma. In Computational and mathematical methods in medicine, 2021, 9971353. doi:10.1155/2021/9971353. https://pubmed.ncbi.nlm.nih.gov/34257701/
5. Li, Wangjian, Ye, Lihong, Chen, Yongliang, Chen, Peng. 2018. P3H4 is correlated with clinicopathological features and prognosis in bladder cancer. In World journal of surgical oncology, 16, 206. doi:10.1186/s12957-018-1507-2. https://pubmed.ncbi.nlm.nih.gov/30322400/
6. Fang, Dengpan, He, Yuanqiao, Yi, Yun, Mei, Jiaqi, Liu, Cundong. 2023. Hub gene associated with prognosis in bladder cancer is a novel therapeutic target. In PeerJ, 11, e15670. doi:10.7717/peerj.15670. https://pubmed.ncbi.nlm.nih.gov/37601252/
7. Liu, Chun-Hui, Zhang, Jun-Jie, Zhang, Qian-Jin, Han, Cong-Hui, Hao, Lin. 2023. METTL3 regulates the proliferation, metastasis and EMT progression of bladder cancer through P3H4. In Cellular signalling, 113, 110971. doi:10.1016/j.cellsig.2023.110971. https://pubmed.ncbi.nlm.nih.gov/37979898/
8. Wan, B, Zeng, Q, Tang, X-Z, Tang, Y-X. . P3H4 affects renal carcinoma through up-regulating miR-1/133a. In European review for medical and pharmacological sciences, 22, 5180-5186. doi:10.26355/eurrev_201808_15714. https://pubmed.ncbi.nlm.nih.gov/30178839/
9. Wang, Guixin, Gao, Yukui, Chen, Yanzhuo, Zhang, Shicheng, Li, Gang. 2022. Identification of Novel Tumor Antigens and the Immune Landscapes of Bladder Cancer Patients for mRNA Vaccine Development. In Frontiers in oncology, 12, 921711. doi:10.3389/fonc.2022.921711. https://pubmed.ncbi.nlm.nih.gov/35814377/
10. Mafficini, Andrea, Simbolo, Michele, Shibata, Tatsuhiro, Scarpa, Aldo, Luchini, Claudio. 2022. Integrative characterization of intraductal tubulopapillary neoplasm (ITPN) of the pancreas and associated invasive adenocarcinoma. In Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 35, 1929-1943. doi:10.1038/s41379-022-01143-2. https://pubmed.ncbi.nlm.nih.gov/36056133/