Milr1-KO 基因敲除小鼠

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产品名称

Milr1-KO 基因敲除小鼠

产品编号

S-KO-09676

品系全称

C57BL/6JCya-Milr1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-380732-Milr1-B6J-VA

品系状态

使用本品系发表的文献需注明: Milr1-KO 基因敲除小鼠 mice (Strain S-KO-09676) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
mast cell immunoglobulin like receptor 1
基因别称
Allergin-1,Gm885,Mca32
染色体号
Chr 11 (Mouse)
转录本 ID
NCBI: NM_001033435 | Ensembl: ENSMUST00000086353
修饰方式
全身性基因敲除
靶向范围
Exon 3~5
敲除长度
~9.2 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2685731Mice homozygous for a null allele have decreased mast cell degranulation and an increased susceptibility to type I hypersensitivity reaction.
Milr1,也称为Mast Cell Immunoglobulin-like Receptor 1(Mast细胞免疫球蛋白样受体1)或Allergin-1,是一种细胞表面免疫受体。它主要在肥大细胞和树突状细胞中表达,并参与抑制免疫球蛋白E(IgE)介导的肥大细胞依赖性反应。Milr1通过与Toll样受体(TLR)-2和TLR-4结合,抑制TLR信号传导,从而调节免疫反应。Milr1的表达和功能与多种生物学过程有关,包括免疫调节、炎症反应和疾病发生。

Milr1在多种疾病中发挥重要作用。在阿尔茨海默病(AD)中,Milr1的表达水平与疾病的严重程度相关。研究表明,Milr1可以调节中枢神经系统的稳态,影响AD的发生和发展。此外,Milr1的表达与过敏性疾病的发生和发展也密切相关。Milr1的突变和表达异常可能导致过敏性疾病的发生,例如哮喘和特应性皮炎。

Milr1在病原体与宿主之间的相互作用中也发挥重要作用。研究表明,Milr1可以抑制宿主免疫反应,从而促进病原体的感染。例如,真菌病原体Valsa mali可以利用其产生的MilRNA Vm-milR1抑制宿主免疫反应,从而促进其感染。此外,真菌病原体Fusarium oxysporum也可以利用其产生的MilRNA Fol-milR1抑制宿主免疫反应,从而促进其感染。

Milr1的表达和功能受多种因素的影响。研究表明,Milr1启动子区域的单核苷酸多态性(SNP)可以影响Milr1的表达水平,从而影响其功能。例如,Milr1启动子区域的SNP rs6504230与过敏性疾病的发生和发展相关。Milr1的表达还受到炎症因子和免疫调节因子的调节,从而影响其功能。

Milr1的研究对于深入理解免疫调节和疾病发生机制具有重要意义。Milr1可以作为疾病诊断和治疗的重要靶点,为疾病的治疗和预防提供新的思路和策略。

综上所述,Milr1是一种重要的细胞表面免疫受体,参与调节免疫反应、炎症反应和疾病发生。Milr1在多种疾病中发挥重要作用,包括阿尔茨海默病、过敏性疾病和病原体感染。Milr1的表达和功能受多种因素的影响。Milr1的研究对于深入理解免疫调节和疾病发生机制具有重要意义,为疾病的治疗和预防提供新的思路和策略[1][2][3][4][5][6][7][8][9][10]。

参考文献:
1. Khayer, Nasibeh, Motamed, Nasrin, Marashi, Sayed-Amir, Goshadrou, Fatemeh. 2023. RT-DOb, a switch gene for the gene pair {Csf1r, Milr1}, can influence the onset of Alzheimer's disease by regulating communication between mast cell and microglia. In PloS one, 18, e0288134. doi:10.1371/journal.pone.0288134. https://pubmed.ncbi.nlm.nih.gov/37410787/
2. Wang, Bing, Sun, Yanfei, Song, Na, Wang, Xiaojie, Kang, Zhensheng. 2017. Puccinia striiformis f. sp. tritici microRNA-like RNA 1 (Pst-milR1), an important pathogenicity factor of Pst, impairs wheat resistance to Pst by suppressing the wheat pathogenesis-related 2 gene. In The New phytologist, 215, 338-350. doi:10.1111/nph.14577. https://pubmed.ncbi.nlm.nih.gov/28464281/
3. Xu, Ming, Li, Guangyao, Guo, Yan, Feng, Hao, Huang, Lili. 2022. A fungal microRNA-like RNA subverts host immunity and facilitates pathogen infection by silencing two host receptor-like kinase genes. In The New phytologist, 233, 2503-2519. doi:10.1111/nph.17945. https://pubmed.ncbi.nlm.nih.gov/34981514/
4. Ji, Hui-Min, Mao, Hui-Ying, Li, Si-Jian, Borkovich, Katherine A, Ouyang, Shou-Qiang. 2021. Fol-milR1, a pathogenicity factor of Fusarium oxysporum, confers tomato wilt disease resistance by impairing host immune responses. In The New phytologist, 232, 705-718. doi:10.1111/nph.17436. https://pubmed.ncbi.nlm.nih.gov/33960431/
5. Nanatsue, Kentaro, Ninomiya, Takahiro, Tsuchiya, Mio, Arinami, Tadao, Noguchi, Emiko. 2014. Influence of MILR1 promoter polymorphism on expression levels and the phenotype of atopy. In Journal of human genetics, 59, 480-3. doi:10.1038/jhg.2014.57. https://pubmed.ncbi.nlm.nih.gov/25007884/
6. Lin, Yu-Hsien, Tahara-Hanaoka, Satoko, Obana, Nozomu, Fukuda, Shinji, Shibuya, Akira. . An inhibitory immunoreceptor Allergin-1 regulates the intestinal dysbiosis and barrier function in mice. In International immunology, 36, 365-371. doi:10.1093/intimm/dxae010. https://pubmed.ncbi.nlm.nih.gov/38442194/
7. Cui, Chunlai, Wang, Yan, Liu, Jingnan, Sun, Peilu, Wang, Sibao. 2019. A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection. In Nature communications, 10, 4298. doi:10.1038/s41467-019-12323-1. https://pubmed.ncbi.nlm.nih.gov/31541102/
8. Khayer, Nasibeh, Marashi, Sayed-Amir, Mirzaie, Mehdi, Goshadrou, Fatemeh. 2017. Three-way interaction model to trace the mechanisms involved in Alzheimer's disease transgenic mice. In PloS one, 12, e0184697. doi:10.1371/journal.pone.0184697. https://pubmed.ncbi.nlm.nih.gov/28934252/
9. López-Cade, Igor, García-Barberán, Vanesa, Cabañas Morafraile, Esther, Győrffy, Balázs, Ocaña, Alberto. 2022. Genomic mapping of copy number variations influencing immune response in breast cancer. In Frontiers in oncology, 12, 975437. doi:10.3389/fonc.2022.975437. https://pubmed.ncbi.nlm.nih.gov/36119512/
10. Akula, Srinivas, Paivandy, Aida, Fu, Zhirong, Pejler, Gunnar, Hellman, Lars. 2020. How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells. In Cells, 9, . doi:10.3390/cells9092118. https://pubmed.ncbi.nlm.nih.gov/32957735/