Tpra1-KO 基因敲除小鼠

下单100%中奖,最高可得千元京东卡
复苏/繁育服务
产品名称

Tpra1-KO 基因敲除小鼠

产品编号

S-KO-07251

品系全称

C57BL/6JCya-Tpra1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-24100-Tpra1-B6J-VA

品系状态

使用本品系发表的文献需注明: Tpra1-KO 基因敲除小鼠 mice (Strain S-KO-07251) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
transmembrane protein, adipocyte asscociated 1
基因别称
40kDa,Gpr175,Tpra40
染色体号
Chr 6 (Mouse)
转录本 ID
NCBI: NM_011906.2 | Ensembl: ENSMUST00000055022
修饰方式
全身性基因敲除
靶向范围
Exon 3~12
敲除长度
~3988 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
TPRA1,也称为Tmprss2、Gpr175或Tpra40,是一种跨膜蛋白,在脂肪细胞中调节。它是一种孤儿G蛋白偶联受体(GPCR),其生理功能尚不完全清楚,但研究表明其在多种生物学过程中发挥作用。TPRA1基因编码的蛋白质在脂肪细胞、心脏细胞和早期胚胎细胞中表达,并可能参与细胞分化和信号传导。

TPRA1在多种疾病中发挥重要作用,包括哮喘、高血压、癌症和抑郁症。在哮喘中,TPRA1基因的遗传和表观遗传变异与哮喘风险相关[1]。在高血压中,TPRA1基因的序列变异与血压水平相关[2]。在癌症中,TPRA1基因的遗传和转录组变异与肿瘤发生和进展相关[3]。在抑郁症中,TPRA1基因的表达与抑郁症易感性和抗抑郁药反应相关[4]。

研究表明,TPRA1基因的遗传和表观遗传变异可能与多种生物学过程相关,包括细胞分化、信号传导、炎症反应和肿瘤发生。TPRA1基因的遗传和转录组变异可能与多种疾病风险相关,包括哮喘、高血压、癌症和抑郁症。TPRA1基因的表达可能与多种生物学过程相关,包括细胞分化和信号传导。

TPRA1基因的生理功能和疾病相关性的研究仍在进行中。未来研究可能揭示TPRA1基因在生物学和疾病中的作用机制,并为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Kogan, Vladimir, Millstein, Joshua, London, Stephanie J, Raby, Benjamin A, Breton, Carrie V. 2019. Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search. In Human heredity, 83, 130-152. doi:10.1159/000489765.
2. Wu, Yan Yan, Briollais, Laurent. 2014. Mixed-effects models for joint modeling of sequence data in longitudinal studies. In BMC proceedings, 8, S92. doi:10.1186/1753-6561-8-S1-S92.
3. Pan, Tao, Gao, Yueying, Xu, Gang, Xu, Juan, Li, Yongsheng. 2022. Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels. In NPJ genomic medicine, 7, 32. doi:10.1038/s41525-022-00304-1.
4. Wang, Qingzhong, Wang, Huizhen, Dwivedi, Yogesh. 2024. Integrated Long Noncoding RNA and Messenger RNA Expression Analysis Identifies Molecules Specifically Associated With Resiliency and Susceptibility to Depression and Antidepressant Response. In Biological psychiatry global open science, 4, 100365. doi:10.1016/j.bpsgos.2024.100365.
5. Singh, Jaskirat, Wen, Xiaohui, Scales, Suzie J. 2015. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. In The Journal of biological chemistry, 290, 29663-75. doi:10.1074/jbc.M115.665810.
6. Hu, Shouye, Jiang, Feng, Song, Huimiao, Yang, Zhi, Guo, Yan. 2024. Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk. In Rheumatology (Oxford, England), , . doi:10.1093/rheumatology/keae654.
7. Zepeda-Batista, José Luis, Núñez-Domínguez, Rafael, Ramírez-Valverde, Rodolfo, Herrera-Ojeda, Jessica Beatriz, Parra-Bracamonte, Gaspar Manuel. 2021. Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle. In Genes, 12, . doi:10.3390/genes12111666.
8. Zhou, Yan, Liu, Jie, Lei, Qiuxia, Cao, Dingguo, Wang, Jie. 2025. Identification of quantitative trait loci and candidate genes associated with growth curve parameters in chinese wenshang barred chickens. In Poultry science, 104, 104767. doi:10.1016/j.psj.2025.104767.
9. Fujimoto, K, Mizukami, Y, Kimura, M, Kobayashi, S, Matsuzaki, M. . Molecular cloning of rat transmembrane domain protein of 40 kDa regulated in adipocytes and its expression in H9c2 cells exposed to ischemic hypoxia and reoxygenation. In Biochimica et biophysica acta, 1518, 173-7. doi:.
10. Aki, Toshihiko, Funakoshi, Takeshi, Nishida-Kitayama, Junko, Mizukami, Yoichi. . TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. In Journal of cellular physiology, 217, 194-206. doi:10.1002/jcp.21492.
参考文献:
1. Kogan, Vladimir, Millstein, Joshua, London, Stephanie J, Raby, Benjamin A, Breton, Carrie V. 2019. Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search. In Human heredity, 83, 130-152. doi:10.1159/000489765. https://pubmed.ncbi.nlm.nih.gov/30669148/
2. Wu, Yan Yan, Briollais, Laurent. 2014. Mixed-effects models for joint modeling of sequence data in longitudinal studies. In BMC proceedings, 8, S92. doi:10.1186/1753-6561-8-S1-S92. https://pubmed.ncbi.nlm.nih.gov/25519347/
3. Pan, Tao, Gao, Yueying, Xu, Gang, Xu, Juan, Li, Yongsheng. 2022. Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels. In NPJ genomic medicine, 7, 32. doi:10.1038/s41525-022-00304-1. https://pubmed.ncbi.nlm.nih.gov/35614079/
4. Wang, Qingzhong, Wang, Huizhen, Dwivedi, Yogesh. 2024. Integrated Long Noncoding RNA and Messenger RNA Expression Analysis Identifies Molecules Specifically Associated With Resiliency and Susceptibility to Depression and Antidepressant Response. In Biological psychiatry global open science, 4, 100365. doi:10.1016/j.bpsgos.2024.100365. https://pubmed.ncbi.nlm.nih.gov/39257693/