Aplnr-KO 基因敲除小鼠

1. Yoshikawa, Masahiro, Asaba, Kensuke, Nakayama, Tomohiro. . The APLNR gene polymorphism rs7119375 is associated with an increased risk of development of essential hypertension in the Chinese population: A meta-analysis. In Medicine, 99, e22418. doi:10.1097/MD.0000000000022418. https://pubmed.ncbi.nlm.nih.gov/33327224/

2. Patel, Shashank J, Sanjana, Neville E, Kishton, Rigel J, Zhang, Feng, Restifo, Nicholas P. 2017. Identification of essential genes for cancer immunotherapy. In Nature, 548, 537-542. doi:10.1038/nature23477. https://pubmed.ncbi.nlm.nih.gov/28783722/

3. Yang, Yuqin, Chen, Meilin, Qiu, Yanbing, Huang, Yumei, Zhang, Wenling. 2022. The Apelin/APLNR system modulates tumor immune response by reshaping the tumor microenvironment. In Gene, 834, 146564. doi:10.1016/j.gene.2022.146564. https://pubmed.ncbi.nlm.nih.gov/35598689/

4. Song, Ke, Yang, Xinyan, An, Geng, Liu, Zhaoting, Zhao, Xiao-Yang. 2022. Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. In Nature communications, 13, 7335. doi:10.1038/s41467-022-34990-3. https://pubmed.ncbi.nlm.nih.gov/36443325/

5. Hennigs, Jan K, Cao, Aiqin, Li, Caiyun G, Snyder, Michael P, Rabinovitch, Marlene. 2020. PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension. In Circulation research, 128, 401-418. doi:10.1161/CIRCRESAHA.119.316339. https://pubmed.ncbi.nlm.nih.gov/33322916/