官网首页 商城首页 智鼠故事
购物车 我的订单 登录 / 注册
集团站群
推荐搜索:
TauTFRCApoeSCN10AC-NKGob/obRag1
首页智鼠商城
Zscan12-KO 基因敲除小鼠

Zscan12-KO 基因敲除小鼠

下单100%中奖，最高可得千元京东卡
复苏/繁育服务
产品名称

Zscan12-KO 基因敲除小鼠

产品编号

S-KO-06096

品系全称

C57BL/6JCya-Zscan12em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-22758-Zscan12-B6J-VA

品系状态

使用本品系发表的文献需注明： Zscan12-KO 基因敲除小鼠 mice (Strain S-KO-06096) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
KO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
zinc finger and SCAN domain containing 12
基因别称
2510038J07Rik，FPM315，Zfp96，mKIAA0426，zfp-96
染色体号
Chr 13 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_016684.2 | Ensembl: ENSMUST00000225545
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~5861 bp
下载方案
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
更多信息
ZSCAN12，全称为zinc finger and SCAN domain containing 12，是一种编码锌指和SCAN结构域的基因。锌指结构是DNA结合蛋白中常见的结构，能够识别并结合特定的DNA序列，参与调控基因表达。SCAN结构域是一种在细胞信号传导和基因表达调控中发挥重要作用的蛋白结构域。因此，ZSCAN12可能参与调控基因表达和细胞信号传导等生物学过程。

根据已发表的文献，ZSCAN12在多种癌症的发生和发展中发挥重要作用。例如，在胃癌中，ZSCAN12的表达与肿瘤浸润淋巴细胞的密度密切相关，可以作为预测胃癌患者预后的生物标志物[1]。在高级别膀胱癌中，ZSCAN12的表达与癌症的级别和病理特征相关，可以作为区分正常组织与癌症、低级别与高级别膀胱癌的生物标志物[2]。此外，ZSCAN12的表达还与子宫内膜癌和宫颈癌的发生相关，可以作为这些癌症的筛查和诊断的生物标志物[3,4,5,6]。

除了在癌症中的作用，ZSCAN12还与前列腺癌的预后相关。研究发现，吸烟与前列腺癌的不良预后相关，而ZSCAN12的表达与吸烟有关，吸烟相关的ZSCAN12甲基化变化可能部分解释了吸烟与前列腺癌不良预后的关联[7]。

此外，ZSCAN12还与精神分裂症的发生相关。通过整合全基因组关联研究和甲基化功能注释数据，研究发现ZSCAN12与精神分裂症的发生相关，可能参与调控精神分裂症的病理过程[8]。

综上所述，ZSCAN12在多种生物学过程中发挥重要作用，包括基因表达调控、细胞信号传导、癌症的发生和发展、前列腺癌的预后以及精神分裂症的发生等。ZSCAN12的研究有助于深入理解这些生物学过程，为相关疾病的治疗和预防提供新的思路和策略。

[1] Wen, Xianyu, Jin, Hye-Yeong, Li, Meihui, Lee, Hye Seung, Kang, Gyeong Hoon. 2022. Methylation statuses of NCOR2, PARK2, and ZSCAN12 signify densities of tumor-infiltrating lymphocytes in gastric carcinoma. In Scientific reports, 12, 862. doi:10.1038/s41598-022-04797-9.

[2] Olkhov-Mitsel, Ekaterina, Savio, Andrea J, Kron, Ken J, Zlotta, Alexandre R, Bapat, Bharati. 2017. Epigenome-Wide DNA Methylation Profiling Identifies Differential Methylation Biomarkers in High-Grade Bladder Cancer. In Translational oncology, 10, 168-177. doi:10.1016/j.tranon.2017.01.001.

[3] Beinse, Guillaume, Borghese, Bruno, Métairie, Marie, Taly, Valérie, Alexandre, Jérôme. . Highly Specific Droplet-Digital PCR Detection of Universally Methylated Circulating Tumor DNA in Endometrial Carcinoma. In Clinical chemistry, 68, 782-793. doi:10.1093/clinchem/hvac020.

[4] Herzog, Chiara, Marín, Fátima, Jones, Allison, Costas, Laura, Widschwendter, Martin. 2022. A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets. In Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 40, 3828-3838. doi:10.1200/JCO.22.00266.

[5] Schreiberhuber, Lena, Herzog, Chiara, Vavourakis, Charlotte D, Obrist, Peter, Widschwendter, Martin. 2022. The WID-qEC test: Performance in a hospital-based cohort and feasibility to detect endometrial and cervical cancers. In International journal of cancer, 152, 1269-1274. doi:10.1002/ijc.34275.

[6] Evans, Iona, Reisel, Daniel, Jones, Allison, Jurkovic, Davor, Widschwendter, Martin. 2023. Performance of the WID-qEC test versus sonography to detect uterine cancers in women with abnormal uterine bleeding (EPI-SURE): a prospective, consecutive observational cohort study in the UK. In The Lancet. Oncology, 24, 1375-1386. doi:10.1016/S1470-2045(23)00466-7.

[7] Shui, Irene M, Wong, Chao-Jen, Zhao, Shanshan, Feng, Ziding, Stanford, Janet L. 2016. Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. In Cancer, 122, 2168-77. doi:10.1002/cncr.30045.

[8] Qi, Xin, Guan, Fanglin, Wen, Yan, Cheng, Bolun, Zhang, Feng. 2019. Integrating genome-wide association study and methylation functional annotation data identified candidate genes and pathways for schizophrenia. In Progress in neuro-psychopharmacology & biological psychiatry, 96, 109736. doi:10.1016/j.pnpbp.2019.109736.

参考文献：
1. Wen, Xianyu, Jin, Hye-Yeong, Li, Meihui, Lee, Hye Seung, Kang, Gyeong Hoon. 2022. Methylation statuses of NCOR2, PARK2, and ZSCAN12 signify densities of tumor-infiltrating lymphocytes in gastric carcinoma. In Scientific reports, 12, 862. doi:10.1038/s41598-022-04797-9. https://pubmed.ncbi.nlm.nih.gov/35039565/
2. Olkhov-Mitsel, Ekaterina, Savio, Andrea J, Kron, Ken J, Zlotta, Alexandre R, Bapat, Bharati. 2017. Epigenome-Wide DNA Methylation Profiling Identifies Differential Methylation Biomarkers in High-Grade Bladder Cancer. In Translational oncology, 10, 168-177. doi:10.1016/j.tranon.2017.01.001. https://pubmed.ncbi.nlm.nih.gov/28167242/
3. Beinse, Guillaume, Borghese, Bruno, Métairie, Marie, Taly, Valérie, Alexandre, Jérôme. . Highly Specific Droplet-Digital PCR Detection of Universally Methylated Circulating Tumor DNA in Endometrial Carcinoma. In Clinical chemistry, 68, 782-793. doi:10.1093/clinchem/hvac020. https://pubmed.ncbi.nlm.nih.gov/35323926/
4. Corona, Rosario I, Seo, Ji-Heui, Lin, Xianzhi, Gayther, Simon A, Lawrenson, Kate. 2020. Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. In Nature communications, 11, 2020. doi:10.1038/s41467-020-15951-0. https://pubmed.ncbi.nlm.nih.gov/32332753/
5. Herzog, Chiara, Marín, Fátima, Jones, Allison, Costas, Laura, Widschwendter, Martin. 2022. A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets. In Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 40, 3828-3838. doi:10.1200/JCO.22.00266. https://pubmed.ncbi.nlm.nih.gov/36001862/
6. Evans, Iona, Reisel, Daniel, Jones, Allison, Jurkovic, Davor, Widschwendter, Martin. 2023. Performance of the WID-qEC test versus sonography to detect uterine cancers in women with abnormal uterine bleeding (EPI-SURE): a prospective, consecutive observational cohort study in the UK. In The Lancet. Oncology, 24, 1375-1386. doi:10.1016/S1470-2045(23)00466-7. https://pubmed.ncbi.nlm.nih.gov/37944542/
7. Schreiberhuber, Lena, Herzog, Chiara, Vavourakis, Charlotte D, Obrist, Peter, Widschwendter, Martin. 2022. The WID-qEC test: Performance in a hospital-based cohort and feasibility to detect endometrial and cervical cancers. In International journal of cancer, 152, 1269-1274. doi:10.1002/ijc.34275. https://pubmed.ncbi.nlm.nih.gov/36056582/
8. Shui, Irene M, Wong, Chao-Jen, Zhao, Shanshan, Feng, Ziding, Stanford, Janet L. 2016. Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. In Cancer, 122, 2168-77. doi:10.1002/cncr.30045. https://pubmed.ncbi.nlm.nih.gov/27142338/

资料下载

S-KO-06096_6J_22758_Zscan12_Exon 2~4_A_strategy.pdf
S-KO-06096_6J_22758_Zscan12_Exon 2~4_A_strategy.pdf
下载
如果您对产品或服务有兴趣，欢迎填写信息联系我们
*
姓名
*
单位
*
电话
*
邮箱
*
需求描述