Asb16-KO 基因敲除小鼠

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产品名称

Asb16-KO 基因敲除小鼠

产品编号

S-KO-05264

品系全称

C57BL/6JCya-Asb16em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-217217-Asb16-B6J-VA

品系状态

使用本品系发表的文献需注明: Asb16-KO 基因敲除小鼠 mice (Strain S-KO-05264) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
ankyrin repeat and SOCS box-containing 16
基因别称
-
染色体号
Chr 11 (Mouse)
转录本 ID
NCBI: NM_148953.3 | Ensembl: ENSMUST00000036467
修饰方式
全身性基因敲除
靶向范围
Exon 1~5
敲除长度
~9236 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
ASB16-AS1是一种长链非编码RNA(lncRNA),在多种癌症中表现出高表达,并参与肿瘤的发生发展。它通过多种机制调节肿瘤细胞的增殖、迁移、侵袭和干细胞特性,影响肿瘤的进程和预后。例如,在结直肠癌中,ASB16-AS1通过与miR-185-5p相互作用,抑制TEAD1的表达,从而抑制肿瘤的进展[1]。在卵巢癌中,ASB16-AS1通过与miR-3918竞争性结合,上调GOLM1的表达,从而促进肿瘤的恶性行为和化疗耐药性[2]。此外,ASB16-AS1还在食管癌、胃癌和胶质瘤中发挥作用,通过靶向不同的miRNA,调节肿瘤细胞的生长、迁移和侵袭[3][4][5]。在泛癌分析中,ASB16-AS1在多种肿瘤组织中表达上调,与不良预后相关,并参与免疫浸润的调节[6]。在骨密度方面,ASB16-AS1基因多态性与骨密度变化相关,可能是骨密度变化的潜在功能基因[7]。此外,ASB16-AS1还与双相情感障碍相关,可能是双相情感障碍的候选基因[8]。

综上所述,ASB16-AS1是一种具有多种功能的lncRNA,参与调节肿瘤的发生发展、免疫浸润和骨密度变化等生物学过程。深入研究ASB16-AS1的功能和机制,有助于揭示肿瘤发生发展的分子机制,为肿瘤的诊断和治疗提供新的思路和策略。

参考文献:
1. Yu, Mingxu, Shi, Changsheng, Xu, Dingyin, Zhuo, Shengye, Yang, Qing. 2021. LncRNA ASB16-AS1 drives proliferation, migration, and invasion of colorectal cancer cells through regulating miR-185-5p/TEAD1 axis. In Cell cycle (Georgetown, Tex.), 21, 1-11. doi:10.1080/15384101.2021.1973700. https://pubmed.ncbi.nlm.nih.gov/34870557/
2. Fan, Yang, Wang, Long, Han, Xuechuang, Zhang, Na, She, Lina. 2023. LncRNA ASB16-AS1 accelerates cellular process and chemoresistance of ovarian cancer cells by regulating GOLM1 expression via targeting miR-3918. In Biochemical and biophysical research communications, 675, 1-9. doi:10.1016/j.bbrc.2023.06.068. https://pubmed.ncbi.nlm.nih.gov/37429067/
3. Wu, Linyong, Liao, Wei, Wang, Xiaodong, Yang, Hong, He, Yun. . Expression, prognosis value, and immune infiltration of lncRNA ASB16-AS1 identified by pan-cancer analysis. In Bioengineered, 12, 10302-10318. doi:10.1080/21655979.2021.1996054. https://pubmed.ncbi.nlm.nih.gov/34709970/
4. Jia, Z, Wang, P S, Yang, Y, Wang, Z H, Wang, W. . [LncRNA ASB16-AS1 regulates the proliferation, migration and invasion of esophageal cancer cells by targeting miR-1258]. In Zhonghua zhong liu za zhi [Chinese journal of oncology], 43, 762-768. doi:10.3760/cma.j.cn112152-20200509-00430. https://pubmed.ncbi.nlm.nih.gov/34289570/
5. Fu, Tao, Ji, Ke, Jin, Li, Bu, Zhaode, Ji, Jiafu. 2020. ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer. In Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 24, 45-59. doi:10.1007/s10120-020-01096-y. https://pubmed.ncbi.nlm.nih.gov/32572790/
6. Oelschlaegel, Diana, Wensch-Dorendorf, Monika, Kopke, Grit, Brenig, Bertram, Swalve, Hermann H. 2022. Functional Variants Associated With CMPK2 and in ASB16 Influence Bovine Digital Dermatitis. In Frontiers in genetics, 13, 859595. doi:10.3389/fgene.2022.859595. https://pubmed.ncbi.nlm.nih.gov/35832195/
7. Zhang, Delong, Zhou, Huanggui, Liu, Jun, Mao, Jie. 2019. Long Noncoding RNA ASB16-AS1 Promotes Proliferation, Migration, and Invasion in Glioma Cells. In BioMed research international, 2019, 5437531. doi:10.1155/2019/5437531. https://pubmed.ncbi.nlm.nih.gov/30949502/
8. Liu, Wei, Zhuang, Rujin, Feng, Shujun, Kapora, Elena, Tan, Wenhua. 2020. Long non-coding RNA ASB16-AS1 enhances cell proliferation, migration and invasion via functioning as a ceRNA through miR-1305/Wnt/β-catenin axis in cervical cancer. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 125, 109965. doi:10.1016/j.biopha.2020.109965. https://pubmed.ncbi.nlm.nih.gov/32058219/