Pycr1-KO 基因敲除小鼠

1. Zheng, Ke, Sha, Nannan, Hou, Guofang, Jiang, Yuhui, Chen, Tao. 2023. IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. In Nature communications, 14, 6117. doi:10.1038/s41467-023-41658-z. https://pubmed.ncbi.nlm.nih.gov/37777542/

2. Wang, Haoyu, Xu, Mu, Zhang, Tong, Wang, Qian, Li, John Zhong. . PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification. In Clinical and translational medicine, 14, e70045. doi:10.1002/ctm2.70045. https://pubmed.ncbi.nlm.nih.gov/39422696/

3. Liang, Sung-Tzu, Audira, Gilbert, Juniardi, Stevhen, Lin, Dar-Shong, Hsiao, Chung-Der. 2019. Zebrafish Carrying pycr1 Gene Deficiency Display Aging and Multiple Behavioral Abnormalities. In Cells, 8, . doi:10.3390/cells8050453. https://pubmed.ncbi.nlm.nih.gov/31091804/

4. Zhang, Lihong, Zhao, Xinyu, Wang, Enqin, Xu, Hongkun, Zhang, Baojun. 2023. PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize. In Translational oncology, 32, 101667. doi:10.1016/j.tranon.2023.101667. https://pubmed.ncbi.nlm.nih.gov/37018868/

5. Li, Ginny Xiaohe, Chen, Lijun, Hsiao, Yi, Zhang, Hui, Nesvizhskii, Alexey I. 2024. Comprehensive proteogenomic characterization of rare kidney tumors. In Cell reports. Medicine, 5, 101547. doi:10.1016/j.xcrm.2024.101547. https://pubmed.ncbi.nlm.nih.gov/38703764/