Sorbs1-KO 基因敲除小鼠

下单100%中奖,最高可得千元京东卡
复苏/繁育服务
产品名称

Sorbs1-KO 基因敲除小鼠

产品编号

S-KO-04296

品系全称

C57BL/6JCya-Sorbs1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-20411-Sorbs1-B6J-VA

品系状态

使用本品系发表的文献需注明: Sorbs1-KO 基因敲除小鼠 mice (Strain S-KO-04296) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
sorbin and SH3 domain containing 1
基因别称
2310065E01Rik,9530001P15Rik,CAP,SH3P12,Sh3d5,mKIAA1296
染色体号
Chr 19 (Mouse)
转录本 ID
NCBI: NM_001403056 | Ensembl: ENSMUST00000224667
修饰方式
全身性基因敲除
靶向范围
Exon 6~7
敲除长度
~1.2 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:700014Mice homozygous for a null allele exhibit decreased triglyceride levels, altered glucose homeostasis, decreased white blood cells and resistance to developing glucose intolerance induced by a high fat diet.
SORBS1,也称为Sorbin和SH3结构域包含1,是一种重要的细胞骨架连接蛋白。SORBS1属于SoHo家族的细胞骨架适配蛋白,具有一个sorbin同源结构域和三个SH3结构域。SORBS1在多种生物学过程中发挥重要作用,包括细胞粘附、迁移、信号转导和细胞骨架组织。SORBS1可以与多种蛋白质相互作用,参与多种信号通路的调节,如FAK/Src信号通路、RhoA信号通路和BMP信号通路等。

在血管和淋巴管发育中,SORBS1起着重要作用。SORBS1可以与BMP信号通路相互作用,调节血管和淋巴管的生长和分化。SORBS1的缺失会导致静脉和淋巴管的发育异常,影响血管和淋巴管的正常功能[2]。

SORBS1在糖尿病的发生发展中也有重要作用。SORBS1参与胰岛素信号转导,调节葡萄糖代谢和胰岛素敏感性。SORBS1的基因多态性与糖尿病的发病风险、发病年龄和葡萄糖稳态相关。SORBS1基因变异可以影响胰岛素信号转导,导致胰岛素抵抗和糖尿病的发生。此外,SORBS1还可以通过调节细胞骨架组织和细胞粘附,影响脂肪组织的炎症反应和胰岛素抵抗的发生[1,3,4,5]。

在结直肠癌中,SORBS1也发挥着重要作用。SORBS1可以与AHNAK相互作用,抑制AHNAK的表达,从而促进结直肠癌细胞的增殖和迁移。此外,SORBS1还可以通过m6A修饰抑制SOX4 mRNA的表达,从而抑制肿瘤的转移。此外,SORBS1还可以通过抑制lncRNA XIST的表达抑制结直肠癌的增殖和转移[6,7]。

综上所述,SORBS1是一种重要的细胞骨架连接蛋白,参与多种生物学过程,包括细胞粘附、迁移、信号转导和细胞骨架组织。SORBS1在多种疾病中发挥重要作用,包括血管和淋巴管发育异常、糖尿病、结直肠癌等。SORBS1的研究有助于深入理解细胞骨架连接蛋白的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Lee, Byung-Cheol, Lee, Jongsoon. 2013. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. In Biochimica et biophysica acta, 1842, 446-62. doi:10.1016/j.bbadis.2013.05.017. https://pubmed.ncbi.nlm.nih.gov/23707515/
2. Veloso, Alexandra, Bleuart, Anouk, Conrard, Louise, Dequiedt, Franck, Martin, Maud. 2024. The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish. In BMC biology, 22, 51. doi:10.1186/s12915-024-01850-z. https://pubmed.ncbi.nlm.nih.gov/38414014/
3. Chang, Tien-Jyun, Wang, Wen-Chang, Hsiung, Chao A, Rotter, Jerome I, Chuang, Lee-Ming. 2018. Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study. In Scientific reports, 8, 10574. doi:10.1038/s41598-018-28891-z. https://pubmed.ncbi.nlm.nih.gov/30002559/
4. Chang, Tien-Jyun, Wang, Wen-Chang, Hsiung, Chao A, Rotter, Jerome, Chuang, Lee-Ming. . Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study. In Medicine, 95, e2970. doi:10.1097/MD.0000000000002970. https://pubmed.ncbi.nlm.nih.gov/26962801/
5. Gong, Siqian, Huo, Shaofeng, Luo, Yingying, Han, Xueyao, Ji, Linong. 2022. A variation in SORBS1 is associated with type 2 diabetes and high-density lipoprotein cholesterol in Chinese population. In Diabetes/metabolism research and reviews, 38, e3524. doi:10.1002/dmrr.3524. https://pubmed.ncbi.nlm.nih.gov/35107206/
6. Cho, Woo-Cheol, Jang, Jee-Eun, Kim, Kyung-Hee, Yoo, Byong-Chul, Ku, Ja-Lok. 2020. SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines. In International journal of oncology, 56, 1140-1151. doi:10.3892/ijo.2020.5006. https://pubmed.ncbi.nlm.nih.gov/32319594/
7. Lin, Yilin, Wang, Wenbo, Wang, Ya, Fu, Kai. . MiR-223-3p increases resistance of colorectal cancer cells to 5-fluorouracil via targeting SORBS1. In Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 48, 356-368. doi:10.11817/j.issn.1672-7347.2023.220345. https://pubmed.ncbi.nlm.nih.gov/37164919/