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Pak1-KO 基因敲除小鼠

复苏/繁育服务

产品名称

Pak1-KO 基因敲除小鼠

产品编号

S-KO-03552

品系全称

C57BL/6NCya-Pak1^em1/Cya

品系背景

C57BL/6NCya

品系编号

KOCMP-18479-Pak1-B6N-VA

品系状态

使用本品系发表的文献需注明： Pak1-KO 基因敲除小鼠 mice (Strain S-KO-03552) were purchased from Cyagen.

交付类型

周龄

性别

基因型

数量

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Knockout (KO)KO小鼠库模型

基本信息

基因研究概述

质控标准

基因

Pak1

基因别称

NCBI ID

18479

染色体号

Chr 7

NCBI RefSeq

NM_011035

Ensembl ID

ENSMUST00000033040

修饰方式

全身性基因敲除

靶向范围

Exon 3

敲除长度

~0.1 kb

下载方案

S-KO-03552_6N_18479_Pak1_Exon 3_strategy.pdf

品系说明

该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。

表型提示

MGI:1339975Mice homozygous for a knock-out allele display defects in allergen-induced mast cell migration and degranulation. Mice homozygous for a different knock-out allele exhibit reduced long term potentiation. A C>T mutation at position 6 in the 3' UTR affects the use of the proximal poly(A) signal and reduces susceptibility to developing papillomas.

发表文献

Experimental Hematology

2023-11-01

Inhibition of PAK1 generates an ameliorative effect on MPLW515L mouse model of myeloproliferative neoplasms by regulating the differentiation and survival of megakaryocytes

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Experimental Hematology

2023-09-22

Inhibition of PAK1 generates an ameliorative effect on MPLW515L mouse model of myeloproliferative neoplasms by regulating the differentiation and survival of the megakaryocytes

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