Lgals9-KO 基因敲除小鼠

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产品名称

Lgals9-KO 基因敲除小鼠

产品编号

S-KO-02885

品系全称

C57BL/6NCya-Lgals9em1/Cya

品系背景

C57BL/6NCya

品系编号

KOCMP-16859-Lgals9-B6N-VA

品系状态

使用本品系发表的文献需注明: Lgals9-KO 基因敲除小鼠 mice (Strain S-KO-02885) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
lectin, galactose binding, soluble 9
基因别称
LGALS35,Lgals5,gal-9,galectin-9
染色体号
Chr 11 (Mouse)
转录本 ID
NCBI: NM_010708 | Ensembl: ENSMUST00000108269
修饰方式
全身性基因敲除
靶向范围
Exon 3~5
敲除长度
~3.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:109496Mice homozygous for a null allele exhibit increased susceptibility to collagen-induced arthritis, increased T-helper 1 cells and decreased regulatory T cells.
Lgals9,也称为Galectin-9,是一种属于凝集素家族的蛋白质,广泛表达于免疫细胞和其他类型的细胞中。Lgals9在免疫调节和肿瘤发生中发挥着重要作用,通过与它的受体Tim-3相互作用来调节免疫稳态和肿瘤细胞生存[3]。此外,Lgals9还可以与细胞表面的糖蛋白CD44结合,参与细胞通讯和细胞死亡调节[7]。

Lgals9在多种疾病中发挥重要作用,包括类风湿性关节炎、中风、癌症和先兆子痫。在类风湿性关节炎中,Lgals9基因多态性与疾病易感性相关,并且Lgals9的表达水平与疾病活动性相关[1,6]。在中风中,Lgals9通过细胞通讯和细胞死亡调节参与神经炎症和神经元损伤[2]。在癌症中,Lgals9的表达与多种癌症的预后相关,并且Lgals9的靶向治疗可以刺激抗肿瘤免疫反应[3,4,5]。在先兆子痫中,Lgals9通过抑制子宫螺旋动脉重塑参与疾病的发病机制[8]。

综上所述,Lgals9是一种重要的免疫调节和肿瘤发生相关蛋白质。Lgals9在多种疾病中发挥重要作用,包括类风湿性关节炎、中风、癌症和先兆子痫。Lgals9的研究有助于深入理解免疫调节和肿瘤发生的机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Xu, Wang-Dong, Wu, Qian, He, Yan-Wei, Zhou, Jie, Liu, Xiao-Yan. 2021. Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis. In Cellular immunology, 368, 104419. doi:10.1016/j.cellimm.2021.104419. https://pubmed.ncbi.nlm.nih.gov/34371260/
2. Han, Bing, Zhou, Shunheng, Zhang, Yuan, Jiang, Wei, Yao, Honghong. 2024. Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain. In Science translational medicine, 16, eadg1323. doi:10.1126/scitranslmed.adg1323. https://pubmed.ncbi.nlm.nih.gov/38324639/
3. Lv, Yan, Ma, Xiao, Ma, Yuxin, Du, Yuxin, Feng, Jifeng. 2022. A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9). In Genes & diseases, 10, 2366-2382. doi:10.1016/j.gendis.2022.05.020. https://pubmed.ncbi.nlm.nih.gov/37554219/
4. Du, Yanhua, Shi, Jintong, Wang, Jiaxin, Li, Zhigang, Ye, Youqiong. . Integration of Pan-Cancer Single-Cell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment. In Cancer research, 84, 192-210. doi:10.1158/0008-5472.CAN-23-1418. https://pubmed.ncbi.nlm.nih.gov/38225927/
5. Ou, Zhihua, Lin, Shitong, Qiu, Jiaying, Li, Junhua, Wu, Peng. 2022. Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9, e2203040. doi:10.1002/advs.202203040. https://pubmed.ncbi.nlm.nih.gov/35986392/
6. Vilar, Kamila de Melo, Pereira, Michelly Cristiny, Tavares Dantas, Andrea, Pinto Duarte, Ângela Luzia Branco, da Rocha Pitta, Maira Galdino. 2019. Galectin-9 gene (LGALS9) polymorphisms are associated with rheumatoid arthritis in Brazilian patients. In PloS one, 14, e0223191. doi:10.1371/journal.pone.0223191. https://pubmed.ncbi.nlm.nih.gov/31600237/
7. Yang, Riyao, Sun, Linlin, Li, Ching-Fei, Yu, Dihua, Hung, Mien-Chie. 2021. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. In Nature communications, 12, 832. doi:10.1038/s41467-021-21099-2. https://pubmed.ncbi.nlm.nih.gov/33547304/
8. Li, Yanhong, Sang, Yifei, Chang, Yunjian, Wu, Ligang, Du, Meirong. 2024. A Galectin-9-Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia. In Circulation, 149, 1670-1688. doi:10.1161/CIRCULATIONAHA.123.064391. https://pubmed.ncbi.nlm.nih.gov/38314577/