Anpep-KO 基因敲除小鼠

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产品名称

Anpep-KO 基因敲除小鼠

产品编号

S-KO-02854

品系全称

C57BL/6JCya-Anpepem1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-16790-Anpep-B6J-VA

品系状态

使用本品系发表的文献需注明: Anpep-KO 基因敲除小鼠 mice (Strain S-KO-02854) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
alanyl aminopeptidase, membrane
基因别称
AP-M,AP-N,Apn,Cd13,P150
染色体号
Chr 7 (Mouse)
转录本 ID
NCBI: NM_008486 | Ensembl: ENSMUST00000107392
修饰方式
全身性基因敲除
靶向范围
Exon 2~21
敲除长度
~21.2 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:5000466Mice homozygous for different knock-out alleles exhibit an increase in CD4+ thymocytes, altered macrophage adhesion, pathological neovascularization and/or altered mammary gland morphology during gestation.
ANPEP(Aminopeptidase N)是一种位于细胞膜上的外酶,属于氨基肽酶家族。它在细胞内外广泛分布,参与蛋白质和肽类的代谢过程。ANPEP通过切割肽链的N端氨基酸,调节多种生物活性肽的浓度,如血管紧张素III和血管紧张素IV,从而影响血压、血管功能和代谢过程。ANPEP还参与炎症反应和免疫应答,调节细胞增殖和凋亡。

ANPEP基因的变异与多种疾病的发生发展相关。研究表明,ANPEP基因的多态性与2型糖尿病(T2DM)及其微血管并发症的发生风险相关。例如,rs13380049位点的变异与T2DM患者中糖尿病视网膜病变和肾病的风险降低相关[1]。此外,ANPEP基因的多态性还与孕妇中先兆子痫的发生风险相关,但这一结果在不同人群中的研究结果并不一致[2]。

ANPEP基因的表达和功能还与非酒精性脂肪肝疾病(NAFLD)相关。研究发现,ANPEP在NAFLD患者的血浆中表达水平升高,并且与肝脏纤维化相关[3]。ANPEP基因的多态性还与T2DM患者的血糖、肝酶和谷胱甘肽等代谢指标相关,提示ANPEP基因可能通过影响谷胱甘肽代谢和氧化还原平衡参与T2DM的发生发展[4]。

ANPEP基因在肿瘤的发生发展中也可能发挥重要作用。研究发现,ANPEP在食管腺癌中表达升高,并且与淋巴管侵犯和患者生存期缩短相关[7]。ANPEP基因的表达还与胃黏膜上皮内瘤变中高风险胃癌前病变相关,提示ANPEP可能作为胃癌早期诊断的分子标志物[8]。

ANPEP基因的表达和功能还与心脏疾病相关。研究发现,ANPEP基因的表达与心衰患者心脏重塑相关,可能与心衰的发病机制相关[6]。此外,ANPEP基因的表达还与肾素-血管紧张素-醛固酮系统(RAAS)抑制剂治疗糖尿病肾病的效果相关,提示ANPEP可能作为治疗糖尿病肾病的潜在靶点[5]。

综上所述,ANPEP基因在多种生物学过程中发挥重要作用,包括代谢、免疫、肿瘤发生和心脏疾病。ANPEP基因的多态性和表达水平与多种疾病的发生发展相关,可能成为疾病诊断和治疗的重要靶点。

参考文献:
1. Korvyakova, Ya E, Azarova, I E, Markina, D D, Solodilova, M A, Polonikov, A V. 2024. Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes. In Bulletin of experimental biology and medicine, 178, 79-85. doi:10.1007/s10517-024-06286-7. https://pubmed.ncbi.nlm.nih.gov/39576474/
2. Khaliq, Olive P, Konoshita, Tadashi, Moodley, Jagidesa, Naicker, Thajasvarie. 2020. The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia. In European journal of obstetrics, gynecology, and reproductive biology, 252, 160-165. doi:10.1016/j.ejogrb.2020.06.037. https://pubmed.ncbi.nlm.nih.gov/32619880/
3. Niu, Lili, Geyer, Philipp E, Wewer Albrechtsen, Nicolai J, Hofmann, Susanna M, Mann, Matthias. 2019. Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease. In Molecular systems biology, 15, e8793. doi:10.15252/msb.20188793. https://pubmed.ncbi.nlm.nih.gov/30824564/
4. Korvyakova, Yaroslava, Azarova, Iuliia, Klyosova, Elena, Solodilova, Maria, Polonikov, Alexey. 2024. The link between the ANPEP gene and type 2 diabetes mellitus may be mediated by the disruption of glutathione metabolism and redox homeostasis. In Gene, 935, 149050. doi:10.1016/j.gene.2024.149050. https://pubmed.ncbi.nlm.nih.gov/39489227/
5. Zhou, Dongqi, Zhou, Ting, Tang, Shiyun, Li, Mingqiao, Chen, Qiu. 2024. Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy. In Frontiers in endocrinology, 15, 1354950. doi:10.3389/fendo.2024.1354950. https://pubmed.ncbi.nlm.nih.gov/38332893/
6. Xie, Rong, Yuan, Shuai, Hu, Guo, Wang, Dao Wen, Li, Huaping. 2024. Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts. In Molecular therapy : the journal of the American Society of Gene Therapy, 32, 1578-1594. doi:10.1016/j.ymthe.2024.03.018. https://pubmed.ncbi.nlm.nih.gov/38475992/
7. Goltsov, Alexei A, Maru, Dipen M, Katkhuda, Riham, Futreal, P Andrew, Hofstetter, Wayne L. 2023. ANPEP/CD13 Expression as a Marker of Lymphovascular Invasion and Survival in Esophageal Adenocarcinoma. In The Annals of thoracic surgery, 118, 241-251. doi:10.1016/j.athoracsur.2023.09.036. https://pubmed.ncbi.nlm.nih.gov/37806335/
8. Huang, Robert J, Wichmann, Ignacio A, Su, Andrew, Hwang, Joo Ha, Ji, Hanlee P. 2023. A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.09.20.558462. https://pubmed.ncbi.nlm.nih.gov/37786704/