Itgb1-KO 基因敲除小鼠

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产品名称

Itgb1-KO 基因敲除小鼠

产品编号

S-KO-02699

品系全称

C57BL/6JCya-Itgb1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-16412-Itgb1-B6J-VA

品系状态

使用本品系发表的文献需注明: Itgb1-KO 基因敲除小鼠 mice (Strain S-KO-02699) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
KO小鼠库模型
PI3K-Akt信号通路

基本信息

基因研究概述

质控标准

基因
基因全称
integrin beta 1 (fibronectin receptor beta)
基因别称
4633401G24Rik,CD29,Fnrb,Gm9863,gpIIa
染色体号
Chr 8 (Mouse)
转录本 ID
NCBI: NM_010578 | Ensembl: ENSMUST00000090006
修饰方式
全身性基因敲除
靶向范围
Exon 3
敲除长度
~0.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96610Homozygous targeted null mutants die at or soon after implantation. Tissue-specific knockouts exhibit skin blisters, hair-loss, brain and heart defects, and impaired immune responses, wound healing, and hematopoietic stem cell migration, respectively.
Itgb1基因,也称为整合素β1亚基基因,编码整合素β1蛋白,属于整合素家族成员。整合素β1蛋白是一种重要的细胞表面受体,参与细胞粘附、迁移、增殖和信号传导等生物学过程。Itgb1基因的表达和功能与多种疾病的发生和发展密切相关。

在环境压力与抑郁症的关系研究中,Itgb1基因的表观遗传变化被发现与抑郁症的发生相关[1]。此外,Itgb1基因的异常表达还与卵巢癌的淋巴管生成和淋巴结转移相关[2]。在糖尿病心肌病中,Itgb1基因介导的细胞间通讯驱动了心肌纤维化的发生[3]。Itgb1基因的表达上调也与非小细胞肺癌细胞的放射抵抗性增强相关[4]。临床外显子组测序发现,Itgb1基因是多种遗传病的重要候选基因[5]。单细胞RNA测序发现,Itgb1基因在骨代谢中发挥重要作用[6]。在肝细胞癌中,Itgb1基因的激活与肿瘤的进展相关[7]。在弥漫性胃癌中,Itgb1基因的表达上调与更差的预后相关[8]。

综上所述,Itgb1基因是一种重要的细胞表面受体,参与多种生物学过程,并与多种疾病的发生和发展密切相关。Itgb1基因的研究有助于深入理解其生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Park, Caroline, Rosenblat, Joshua D, Brietzke, Elisa, Kalantarova, Anastasia, McIntyre, Roger S. 2019. Stress, epigenetics and depression: A systematic review. In Neuroscience and biobehavioral reviews, 102, 139-152. doi:10.1016/j.neubiorev.2019.04.010. https://pubmed.ncbi.nlm.nih.gov/31005627/
2. Sun, Rui, Yuan, Lin, Jiang, Yi, Zhang, Lin, Cheng, Wenjun. 2023. ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer. In Theranostics, 13, 833-848. doi:10.7150/thno.77441. https://pubmed.ncbi.nlm.nih.gov/36632222/
3. Li, Wei, Lou, Xinqi, Zha, Yingjie, Zhang, Zhenhao, Qiao, Shigang. 2023. Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy. In eLife, 12, . doi:10.7554/eLife.80479. https://pubmed.ncbi.nlm.nih.gov/37010266/
4. Li, Yuexian, Sun, Cheng, Tan, Yonggang, Li, Yuchao, Zou, Huawei. 2021. ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition. In International journal of biological sciences, 17, 635-650. doi:10.7150/ijbs.52319. https://pubmed.ncbi.nlm.nih.gov/33613118/
5. Gorukmez, Ozlem, Gorukmez, Orhan, Topak, Ali. 2023. Clinical exome sequencing findings in 1589 patients. In American journal of medical genetics. Part A, 191, 1557-1564. doi:10.1002/ajmg.a.63190. https://pubmed.ncbi.nlm.nih.gov/36964972/
6. Qiu, Xiang, Liu, Ying, Shen, Hui, Xiao, Hong-Mei, Deng, Hong-Wen. 2021. Single-cell RNA sequencing of human femoral head in vivo. In Aging, 13, 15595-15619. doi:10.18632/aging.203124. https://pubmed.ncbi.nlm.nih.gov/34111027/
7. Zhengdong, Ai, Xiaoying, Xing, Shuhui, Fu, Xi, Tang, Wanqian, Liu. 2024. Identification of fatty acids synthesis and metabolism-related gene signature and prediction of prognostic model in hepatocellular carcinoma. In Cancer cell international, 24, 130. doi:10.1186/s12935-024-03306-4. https://pubmed.ncbi.nlm.nih.gov/38584256/
8. Luo, Wen, Lin, Zetong, Chen, Jiahui, Nie, Qinghua, Zhang, Xiquan. 2021. TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration. In Journal of cachexia, sarcopenia and muscle, 12, 1704-1723. doi:10.1002/jcsm.12767. https://pubmed.ncbi.nlm.nih.gov/34427057/