Ankrd6-KO 基因敲除小鼠

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产品名称

Ankrd6-KO 基因敲除小鼠

产品编号

S-KO-01964

品系全称

C57BL/6JCya-Ankrd6em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-140577-Ankrd6-B6J-VA

品系状态

使用本品系发表的文献需注明: Ankrd6-KO 基因敲除小鼠 mice (Strain S-KO-01964) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
KO小鼠库模型
Wnt信号通路

基本信息

基因研究概述

质控标准

基因
基因全称
ankyrin repeat domain 6
基因别称
-
染色体号
Chr 4 (Mouse)
转录本 ID
NCBI: NM_001012450 | Ensembl: ENSMUST00000035719
修饰方式
全身性基因敲除
靶向范围
Exon 3
敲除长度
~0.3 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2154278Mice homozygous for a null mutation display sporadic disruption of utricle hair cell polarity but normal cochlear and vestibular hair cell morphology.
ANKRD6,也称为Ankyrin repeat domain-containing protein 6,是一种包含六个Ankyrin重复结构域的蛋白质。Ankyrin重复结构域是一种保守的蛋白质结构域,广泛存在于各种蛋白质中,参与蛋白质-蛋白质相互作用。ANKRD6在多种组织和器官中表达,包括大脑、脊髓和心脏。研究表明,ANKRD6在哺乳动物早期发育中发挥重要作用,与多种生物学过程相关,包括细胞极性、组织形态发生和器官发育。

ANKRD6与Wnt/planar cell polarity (PCP)信号通路密切相关。Wnt信号通路是细胞信号传导的重要途径之一,参与调节细胞分化和组织形态发生。PCP是Wnt信号通路的一个分支,负责控制细胞极性和细胞运动。ANKRD6是PCP信号通路的核心分子之一,与Frizzled、Dishevelled、Vangl、Prickle和Diego等蛋白质相互作用,共同调节PCP信号传导。

ANKRD6在多种癌症中发挥重要作用,包括结直肠癌、胃癌和神经管缺陷。研究发现,ANKRD6在结直肠癌和胃癌细胞中高表达,与患者的预后不良相关。此外,ANKRD6在神经管缺陷中也发挥重要作用,其基因突变与神经管缺陷的发生有关。

除了在癌症和神经管缺陷中的作用外,ANKRD6还与肌肉和运动表型相关。研究表明,ANKRD6基因的变异与肌肉大小、力量和运动习惯相关。这表明ANKRD6在肌肉发育和运动调节中也发挥作用。

综上所述,ANKRD6是一种重要的蛋白质,参与调节细胞极性、组织形态发生和器官发育。ANKRD6在多种疾病中发挥重要作用,包括癌症、神经管缺陷和肌肉发育。ANKRD6的研究有助于深入理解其生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略[1,2,3,4,5,6,7,8,9,10]。

参考文献:
1. Shi, De-Li. 2022. Planar cell polarity regulators in asymmetric organogenesis during development and disease. In Journal of genetics and genomics = Yi chuan xue bao, 50, 63-76. doi:10.1016/j.jgg.2022.06.007. https://pubmed.ncbi.nlm.nih.gov/35809777/
2. Zhao, H, Liu, G, Li, Y, Yang, N, Zhao, J. . [High expression of ANKRD6 is an indicator for poor prognosis of colon adenocarcinoma]. In Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 43, 1715-1724. doi:10.12122/j.issn.1673-4254.2023.10.09. https://pubmed.ncbi.nlm.nih.gov/37933647/
3. Elizazu, Joseba, Artetxe-Zurutuza, Aizpea, Otaegi-Ugartemendia, Maddalen, Matheu, Ander, Carrasco-Garcia, Estefania. 2024. Identification of a novel gene signature related to prognosis and metastasis in gastric cancer. In Cellular oncology (Dordrecht, Netherlands), 47, 1355-1373. doi:10.1007/s13402-024-00932-y. https://pubmed.ncbi.nlm.nih.gov/38480611/
4. Bai, Rui, Wu, Dehao, Shi, Zhong, Yuan, Ying, Zheng, Shu. . Pan-cancer analyses demonstrate that ANKRD6 is associated with a poor prognosis and correlates with M2 macrophage infiltration in colon cancer. In Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 33, 93-102. doi:10.21147/j.issn.1000-9604.2021.01.10. https://pubmed.ncbi.nlm.nih.gov/33707932/
5. Jones, Chonnettia, Qian, Dong, Kim, Sun Myoung, Chi, Fanglu, Chen, Ping. 2014. Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. In Developmental biology, 395, 62-72. doi:10.1016/j.ydbio.2014.08.029. https://pubmed.ncbi.nlm.nih.gov/25218921/
6. Tissir, F, Bar, I, Goffinet, A M, Lambert De Rouvroit, C. . Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. In Developmental dynamics : an official publication of the American Association of Anatomists, 224, 465-9. doi:. https://pubmed.ncbi.nlm.nih.gov/12203740/
7. Katoh, Masuko, Katoh, Masaru. . Identification and characterization of rat Ankrd6 gene in silico. In International journal of molecular medicine, 15, 359-63. doi:. https://pubmed.ncbi.nlm.nih.gov/15647854/
8. Allache, Redouane, Wang, Mingqin, De Marco, Patrizia, Capra, Valeria, Kibar, Zoha. 2014. Genetic studies of ANKRD6 as a molecular switch between Wnt signaling pathways in human neural tube defects. In Birth defects research. Part A, Clinical and molecular teratology, 103, 20-6. doi:10.1002/bdra.23273. https://pubmed.ncbi.nlm.nih.gov/25200652/
9. Van Deveire, Katherine N, Scranton, Sarah K, Kostek, Mathew A, Maresh, Carl M, Pescatello, Linda S. . Variants of the ankyrin repeat domain 6 gene (ANKRD6) and muscle and physical activity phenotypes among European-derived American adults. In Journal of strength and conditioning research, 26, 1740-8. doi:10.1519/JSC.0b013e31825c2bef. https://pubmed.ncbi.nlm.nih.gov/22580979/
10. Katoh, Masaru. . WNT/PCP signaling pathway and human cancer (review). In Oncology reports, 14, 1583-8. doi:. https://pubmed.ncbi.nlm.nih.gov/16273260/