Lsr-flox 基因敲除小鼠

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产品名称

Lsr-flox 基因敲除小鼠

产品编号

S-CKO-19014

品系全称

C57BL/6JCya-Lsrem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-54135-Lsr-B6J-VB

品系状态

使用本品系发表的文献需注明: Lsr-flox 基因敲除小鼠 mice (Strain S-CKO-19014) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
lipolysis stimulated lipoprotein receptor
基因别称
ILDR3,Lisch7
染色体号
Chr 7 (Mouse)
转录本 ID
NCBI: NM_017405 | Ensembl: ENSMUST00000001279
修饰方式
条件性基因敲除
靶向范围
Exon 1~2
敲除长度
~1.9 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1927471Homozygous null mice display embryonic lethality during fetal growth and development, liver hypoplasia, and variable penetrance of pallor, hemorrhaging, superficial skin detachment, and reduced size.
LSR,也称为Lipolysis-stimulated lipoprotein receptor,是一种编码脂蛋白受体的基因。LSR基因编码的蛋白在脂蛋白的内吞作用和细胞间的紧密连接中发挥重要作用。LSR蛋白在细胞膜、细胞质和细胞核中均有表达,其功能与细胞代谢和信号通路相关,可能影响肿瘤的发生和进展。

在动脉粥样硬化中,LSR基因的表达和功能与疾病的发生和进展密切相关。研究表明,LSR基因的突变可能导致婴儿期肝内胆汁淤积症,这是一种与肝脏细胞间紧密连接形成相关的疾病[3]。此外,LSR基因的突变还可能影响Klebsiella michiganensis菌株对铜的耐受性,从而影响微生物的生存和生物膜的形成[6]。

LSR基因的表达和功能在乳腺癌和肺癌中也有研究。研究发现,LSR基因在乳腺癌细胞中高表达,并且与不良预后相关[7]。LSR基因在肺癌细胞中也有表达,并且可能促进肺癌细胞的增殖和侵袭[8]。

此外,LSR基因的表达和功能还与年龄相关的脑内胆固醇代谢变化相关。研究发现,LSR基因在小鼠脑中的表达具有区域特异性,并且在老年小鼠中观察到LSR基因表达的变化,这可能与年龄相关的胆固醇代谢变化有关[9]。

综上所述,LSR基因是一种重要的基因,编码的蛋白在脂蛋白的内吞作用和细胞间的紧密连接中发挥重要作用。LSR基因的表达和功能与多种疾病的发生和进展密切相关,包括动脉粥样硬化、胆汁淤积症、铜耐受性、乳腺癌和肺癌。LSR基因的研究有助于深入理解脂蛋白代谢和细胞信号通路的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略[1,2,4,5,10]。

参考文献:
1. Pan, Huize, Ho, Sebastian E, Xue, Chenyi, Zhang, Hanrui, Reilly, Muredach P. 2024. Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease. In Circulation, 149, 1885-1898. doi:10.1161/CIRCULATIONAHA.123.067587. https://pubmed.ncbi.nlm.nih.gov/38686559/
2. Bashore, Alexander C, Yan, Hanying, Xue, Chenyi, Li, Mingyao, Reilly, Muredach P. 2024. High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis. In Arteriosclerosis, thrombosis, and vascular biology, 44, 930-945. doi:10.1161/ATVBAHA.123.320524. https://pubmed.ncbi.nlm.nih.gov/38385291/
3. Uehara, Tomoko, Yamada, Mamiko, Umetsu, Shuichiro, Inui, Ayano, Kosaki, Kenjiro. 2020. Biallelic Mutations in the LSR Gene Cause a Novel Type of Infantile Intrahepatic Cholestasis. In The Journal of pediatrics, 221, 251-254. doi:10.1016/j.jpeds.2020.01.064. https://pubmed.ncbi.nlm.nih.gov/32303357/
4. An, Ding, Schneller, Jessica L, Frassetto, Andrea, Venditti, Charles P, Martini, Paolo G V. . Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia. In Cell reports, 21, 3548-3558. doi:10.1016/j.celrep.2017.11.081. https://pubmed.ncbi.nlm.nih.gov/29262333/
5. Galicia-Garcia, Unai, Benito-Vicente, Asier, Uribe, Kepa B, Palacios, Lourdes, Martin, Cesar. 2020. Mutation type classification and pathogenicity assignment of sixteen missense variants located in the EGF-precursor homology domain of the LDLR. In Scientific reports, 10, 1727. doi:10.1038/s41598-020-58734-9. https://pubmed.ncbi.nlm.nih.gov/32015373/
6. Gao, Ya, Peng, Dongyu, Wang, Xinlong, Lin, Shanshan. 2024. Effects of the quorum sensing related luxS gene and lsr operon on Klebsiella michiganensis resisting copper stress. In Environmental research, 256, 119244. doi:10.1016/j.envres.2024.119244. https://pubmed.ncbi.nlm.nih.gov/38810822/
7. Reaves, Denise K, Hoadley, Katherine A, Fagan-Solis, Katerina D, Perou, Charles M, Fleming, Jodie M. 2016. Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis. In Molecular cancer research : MCR, 15, 165-178. doi:10.1158/1541-7786.MCR-16-0085-T. https://pubmed.ncbi.nlm.nih.gov/27856957/
8. Zhang, Min, Ma, Cui. 2021. LSR Promotes Cell Proliferation and Invasion in Lung Cancer. In Computational and mathematical methods in medicine, 2021, 6651907. doi:10.1155/2021/6651907. https://pubmed.ncbi.nlm.nih.gov/33763152/
9. El Hajj, Aseel, Yen, Frances T, Oster, Thierry, Lanhers, Marie-Claire, Claudepierre, Thomas. 2019. Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brain. In PloS one, 14, e0218812. doi:10.1371/journal.pone.0218812. https://pubmed.ncbi.nlm.nih.gov/31233547/
10. Bashore, Alexander C, Xue, Chenyi, Kim, Eunyoung, Li, Mingyao, Reilly, Muredach P. 2024. Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States. In Circulation research, 135, 685-700. doi:10.1161/CIRCRESAHA.124.324457. https://pubmed.ncbi.nlm.nih.gov/39105287/