Adgrb3-flox 基因敲除小鼠

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产品名称

Adgrb3-flox 基因敲除小鼠

产品编号

S-CKO-18268

品系全称

C57BL/6JCya-Adgrb3em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-210933-Adgrb3-B6J-VB

品系状态

使用本品系发表的文献需注明: Adgrb3-flox 基因敲除小鼠 mice (Strain S-CKO-18268) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
adhesion G protein-coupled receptor B3
基因别称
A830096D10Rik,Bai3
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_175642 | Ensembl: ENSMUST00000151309
修饰方式
条件性基因敲除
靶向范围
Exon 8~9
敲除长度
~1.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2441837Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology.
Adgrb3,也称为BAI3(Brain-specific angiogenesis inhibitor 3),是一种属于粘附G蛋白偶联受体(adhesion GPCRs)家族的基因。Adgrb3基因编码的蛋白质在脑组织中表达,并在许多生物学过程中发挥作用,包括细胞信号传导、细胞粘附、细胞迁移、血管生成和神经系统的发育[3]。Adgrb3基因的表达异常与多种疾病相关,包括癌症、神经发育障碍和心血管疾病。

Adgrb3基因在结直肠癌(CRC)中的作用已被广泛研究。一项基于TCGA数据的生物信息学分析发现,Adgrb3在CRC中表达下调,并与患者的预后相关。进一步的研究表明,Adgrb3可能是CRC的潜在治疗靶点和新型生物标志物[1]。此外,Adgrb3基因的突变也与神经发育障碍相关。一项研究发现,Adgrb3基因的双等位基因重复与智力障碍、小脑萎缩和行为障碍相关[2]。此外,Adgrb3基因的多态性与焦虑气质相关,表明其在精神疾病中可能发挥作用[4]。

除了在癌症和神经发育障碍中的作用外,Adgrb3基因在其他疾病中也表现出重要作用。例如,在慢性鼻窦炎伴鼻息肉(CRSwNP)中,Adgrb3在鼻腔黏膜的纤维母细胞中表达,并与疾病的发展相关[5]。在绵羊中,Adgrb3基因的变异与对胃肠道线虫的抵抗性相关[6]。在小细胞肺癌(SCLC)中,Adgrb3基因的变异与患者的生存率相关[7]。在胎儿过度生长中,Adgrb3基因的甲基化水平与出生体重相关[8]。此外,Adgrb3基因的表达与脑肿瘤的预后相关[9]。在奶牛中,Adgrb3基因与乳房形状特征相关[10]。

综上所述,Adgrb3基因在多种疾病中发挥重要作用,包括癌症、神经发育障碍、心血管疾病和其他疾病。Adgrb3基因的突变、表达异常和表观遗传修饰与疾病的易感性、发展和预后相关。进一步研究Adgrb3基因的功能和机制对于理解疾病的发生机制、开发新的治疗方法和改善患者的预后具有重要意义。

参考文献:
1. Zhang, Yu, Luo, Jia, Liu, Zhe, Wang, Lei, Song, Xinqiang. . Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas. In Bioscience reports, 41, . doi:10.1042/BSR20211280. https://pubmed.ncbi.nlm.nih.gov/34308980/
2. Scuderi, Carmela, Saccuzzo, Lucia, Vinci, Mirella, Romano, Corrado, Fichera, Marco. 2019. Biallelic intragenic duplication in ADGRB3 (BAI3) gene associated with intellectual disability, cerebellar atrophy, and behavioral disorder. In European journal of human genetics : EJHG, 27, 594-602. doi:10.1038/s41431-018-0321-1. https://pubmed.ncbi.nlm.nih.gov/30659260/
3. Hamann, Jörg, Aust, Gabriela, Araç, Demet, Langenhan, Tobias, Schiöth, Helgi B. . International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. In Pharmacological reviews, 67, 338-67. doi:10.1124/pr.114.009647. https://pubmed.ncbi.nlm.nih.gov/25713288/
4. Gonda, Xenia, Eszlari, Nora, Torok, Dora, Juhasz, Gabriella, Bagdy, Gyorgy. 2021. Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene. In Translational psychiatry, 11, 337. doi:10.1038/s41398-021-01436-1. https://pubmed.ncbi.nlm.nih.gov/34075027/
5. Wang, Yakun, Li, Zufei, Lu, Jun. 2024. Single-cell RNA sequencing reveals the epithelial cell, fibroblast, and key gene alterations in chronic rhinosinusitis with nasal polyps. In Scientific reports, 14, 2270. doi:10.1038/s41598-024-52341-8. https://pubmed.ncbi.nlm.nih.gov/38280891/
6. Becker, Gabrielle M, Burke, Joan M, Lewis, Ronald M, Notter, David R, Murdoch, Brenda M. 2022. Variants Within Genes EDIL3 and ADGRB3 are Associated With Divergent Fecal Egg Counts in Katahdin Sheep at Weaning. In Frontiers in genetics, 13, 817319. doi:10.3389/fgene.2022.817319. https://pubmed.ncbi.nlm.nih.gov/35360858/
7. Jiang, Yuxin, Xie, Jingyuan, Cheng, Qinpei, Lv, Tangfeng, Zhan, Ping. 2024. Comprehensive genomic and spatial immune infiltration analysis of survival outliers in extensive-stage small cell lung cancer receiving first-line chemoimmunotherapy. In International immunopharmacology, 141, 112901. doi:10.1016/j.intimp.2024.112901. https://pubmed.ncbi.nlm.nih.gov/39151386/
8. Yang, Meng-Nan, Huang, Rong, Zheng, Tao, Li, Jiong, Luo, Zhong-Cheng. 2022. Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors. In Clinical epigenetics, 14, 192. doi:10.1186/s13148-022-01412-6. https://pubmed.ncbi.nlm.nih.gov/36585686/
9. Namiot, E D, Zembatov, G M, Tregub, P P. 2024. Insights into brain tumor diagnosis: exploring in situ hybridization techniques. In Frontiers in neurology, 15, 1393572. doi:10.3389/fneur.2024.1393572. https://pubmed.ncbi.nlm.nih.gov/39022728/
10. Nazar, Mudasir, Abdalla, Ismail Mohamed, Chen, Zhi, Yang, Zhangping, Lu, Xubin. 2022. Genome-Wide Association Study for Udder Conformation Traits in Chinese Holstein Cattle. In Animals : an open access journal from MDPI, 12, . doi:10.3390/ani12192542. https://pubmed.ncbi.nlm.nih.gov/36230283/