Pum2-flox 基因敲除小鼠

1. Gong, Yuanyuan, Liu, Zukai, Yuan, Yihang, Lin, Haifan, Liu, Sanhong. 2022. PUMILIO proteins promote colorectal cancer growth via suppressing p21. In Nature communications, 13, 1627. doi:10.1038/s41467-022-29309-1. https://pubmed.ncbi.nlm.nih.gov/35338151/

2. Yoon, Dong Suk, Choi, Yoorim, Lee, Kyoung-Mi, Park, Kwang Hwan, Lee, Jin Woo. 2023. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. In Journal of biomedical science, 30, 26. doi:10.1186/s12929-023-00920-8. https://pubmed.ncbi.nlm.nih.gov/37088847/

3. Lee, Myon-Hee, Wu, Xinjun, Zhu, Yong. 2019. RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs. In Journal of cellular physiology, 235, 3874-3885. doi:10.1002/jcp.29281. https://pubmed.ncbi.nlm.nih.gov/31595981/

4. Liu, Zhenhua, Lv, Chunye. 2022. RNA binding protein PUM2 promotes hepatocellular carcinoma proliferation and apoptosis via binding to the 3'UTR of BTG3. In Oncology letters, 24, 346. doi:10.3892/ol.2022.13466. https://pubmed.ncbi.nlm.nih.gov/36072004/

5. Schieweck, Rico, Schöneweiss, Elisa-Charlott, Harner, Max, Popper, Bastian, Kiebler, Michael A. 2021. Pumilio2 Promotes Growth of Mature Neurons. In International journal of molecular sciences, 22, . doi:10.3390/ijms22168998. https://pubmed.ncbi.nlm.nih.gov/34445704/