Ct55 深入了解基因-突变-疾病-模型全维度数据，尽在Rare Disease Data Center（RDDC）综合数据库

MGI:1922263 Mice homozygous for a null allele show reduced susceptibility to weight loss, rectal prolapse and visible tumors in an AOM/DSS model of colitis and tumorogenesis. Mice homozygous for a different null allele show a progressive decline in male fertility along with defects in acrosome development, sperm individualization, excess cytoplasm removal and cumulus-oocyte complex penetration capacity, and an impaired autophagic process during spermatogenesis.