Aggf1-flox 基因敲除小鼠

1. Zhang, Teng, Yao, Yufeng, Wang, Jingjing, Chen, Qiuyun, Wang, Qing Kenneth. . Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. In Human molecular genetics, 25, 5094-5110. doi:10.1093/hmg/ddw273. https://pubmed.ncbi.nlm.nih.gov/27522498/

2. Chen, Di, Li, Lei, Tu, Xin, Yin, Zhan, Wang, Qing. 2012. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. In Human molecular genetics, 22, 963-76. doi:10.1093/hmg/dds501. https://pubmed.ncbi.nlm.nih.gov/23197652/

3. Zhang, Xin, Sun, Huimin, Chen, Wanyuan, He, Xianglei. 2019. Elevated expression of AGGF1 predicts poor prognosis and promotes the metastasis of colorectal cancer. In BMC cancer, 19, 1252. doi:10.1186/s12885-019-6474-7. https://pubmed.ncbi.nlm.nih.gov/31881864/

4. Hu, Fang-Yuan, Wu, Chong, Li, Yang, Cao, Huiqing, Tian, Xiao-Li. 2013. AGGF1 is a novel anti-inflammatory factor associated with TNF-α-induced endothelial activation. In Cellular signalling, 25, 1645-53. doi:10.1016/j.cellsig.2013.04.007. https://pubmed.ncbi.nlm.nih.gov/23628701/