Dhodh-flox 基因敲除小鼠

1. Mao, Chao, Liu, Xiaoguang, Zhang, Yilei, Olszewski, Kellen, Gan, Boyi. 2021. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. In Nature, 593, 586-590. doi:10.1038/s41586-021-03539-7. https://pubmed.ncbi.nlm.nih.gov/33981038/

2. Zhu, Yifan, Jiang, Chenyu, He, Jian, Zhang, Hao, Liu, Yiwei. 2024. Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model. In The Journal of clinical investigation, 134, . doi:10.1172/JCI175645. https://pubmed.ncbi.nlm.nih.gov/38690728/

3. Mullen, Nicholas J, Shukla, Surendra K, Thakur, Ravi, Hollingsworth, Michael A, Singh, Pankaj K. 2024. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. In eLife, 12, . doi:10.7554/eLife.87292. https://pubmed.ncbi.nlm.nih.gov/38973593/

4. Yang, Kai, Fu, Li-Man, Chu, Xiao-Yang, Yin, Cheng-Hong, Guo, Qing. 2023. Assessment of a novel variation in DHODH gene causing Miller syndrome: The first report in Chinese population. In Molecular genetics & genomic medicine, 11, e2186. doi:10.1002/mgg3.2186. https://pubmed.ncbi.nlm.nih.gov/37120754/