Tdp2-flox 基因敲除小鼠

1. Gómez-Herreros, Fernando, Zagnoli-Vieira, Guido, Ntai, Ioanna, Herrero-Ruíz, Andrés, Caldecott, Keith W. 2017. TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. In Nature communications, 8, 233. doi:10.1038/s41467-017-00307-y. https://pubmed.ncbi.nlm.nih.gov/28794467/

2. Manguso, Nicholas, Kim, Minhyung, Joshi, Neeraj, You, Sungyong, Tanaka, Hisashi. 2024. TDP2 is a regulator of estrogen-responsive oncogene expression. In NAR cancer, 6, zcae016. doi:10.1093/narcan/zcae016. https://pubmed.ncbi.nlm.nih.gov/38596431/

3. Huang, Shar-Yin N, Dalla Rosa, Ilaria, Michaels, Stephanie A, Kelley, Shana O, Pommier, Yves. 2018. Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform. In EMBO reports, 19, . doi:10.15252/embr.201642139. https://pubmed.ncbi.nlm.nih.gov/29438979/

4. Holmes, Autumn C, Zagnoli-Vieira, Guido, Caldecott, Keith W, Semler, Bert L. 2020. Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation. In Viruses, 12, . doi:10.3390/v12020166. https://pubmed.ncbi.nlm.nih.gov/32023921/

5. Gómez-Herreros, Fernando, Schuurs-Hoeijmakers, Janneke H M, McCormack, Mark, de Vries, Bert B A, Caldecott, Keith W. 2014. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. In Nature genetics, 46, 516-21. doi:10.1038/ng.2929. https://pubmed.ncbi.nlm.nih.gov/24658003/