Hao2-flox 基因敲除小鼠

1. Mattu, Sandra, Fornari, Francesca, Quagliata, Luca, Giordano, Silvia, Columbano, Amedeo. 2015. The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. In Journal of hepatology, 64, 891-8. doi:10.1016/j.jhep.2015.11.029. https://pubmed.ncbi.nlm.nih.gov/26658681/

2. Zuo, Deyu, Luo, Minghao, Liu, Chengxuan, He, An, Li, Xunjia. 2024. HAO2 protects from proximal tubular cells injured in rats with chronic kidney disease by promoting fatty acid metabolic processes. In Biochimica et biophysica acta. Molecular basis of disease, 1870, 167342. doi:10.1016/j.bbadis.2024.167342. https://pubmed.ncbi.nlm.nih.gov/39002705/

3. Xiao, Wen, Wang, Xuegang, Wang, Tao, Chen, Bin, Xing, Jinchun. 2019. HAO2 inhibits malignancy of clear cell renal cell carcinoma by promoting lipid catabolic process. In Journal of cellular physiology, 234, 23005-23016. doi:10.1002/jcp.28861. https://pubmed.ncbi.nlm.nih.gov/31127626/

4. Li, Yuxuan, Zhang, Mingchao, Li, Xiuling, Li, Xiaofang, Sun, Suofeng. 2022. Hydroxyacid Oxidase 2 (HAO2) Inhibits the Tumorigenicity of Hepatocellular Carcinoma and Is Negatively Regulated by miR-615-5p. In Journal of immunology research, 2022, 5003930. doi:10.1155/2022/5003930. https://pubmed.ncbi.nlm.nih.gov/35528616/