MGI:2686519Mice homozygous for a null allele exhibit male infertility with epididymis degeneration, impaired sperm migration in female genital tract, impaired binding of sperm to zona pellucida, and decreased fertilization frequency.
Nicol1,也称为Nucleic acid-binding protein 1,是一种在真核生物中广泛存在的RNA结合蛋白。Nicol1在RNA代谢中发挥着重要作用,参与RNA的转运、定位和稳定,进而影响基因表达和生物学过程。Nicol1通过与RNA上的特定序列结合,调控RNA的稳定性和功能,进而影响基因表达和生物学过程。Nicol1在多种生物学过程中发挥着重要作用,包括细胞分化、发育、代谢和疾病发生。