Map3k9-flox 基因敲除小鼠

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产品名称

Map3k9-flox 基因敲除小鼠

产品编号

S-CKO-10787

品系全称

C57BL/6JCya-Map3k9em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-338372-Map3k9-B6J-VA

品系状态

使用本品系发表的文献需注明: Map3k9-flox 基因敲除小鼠 mice (Strain S-CKO-10787) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型
MAPK信号通路

基本信息

基因研究概述

质控标准

基因
基因全称
mitogen-activated protein kinase kinase kinase 9
基因别称
E130314H24Rik,Mlk1,Prke1
染色体号
Chr 12 (Mouse)
转录本 ID
NCBI: NM_001174107 | Ensembl: ENSMUST00000035987
修饰方式
条件性基因敲除
靶向范围
Exon 4
敲除长度
~1.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2449952Mice homozygous for a reporter/null allele exhibit normal development, reproduction and lifespan.
Map3k9(Mitogen-activated protein kinase kinase kinase 9)是一种丝氨酸/苏氨酸激酶,属于MAP3K家族,是MAPK信号传导途径中的关键成员。MAPK信号传导途径在细胞增殖、分化、凋亡以及炎症反应等多种生物学过程中发挥重要作用。Map3k9通过激活下游的MAP2K和MAPK激酶,参与调节JNK、ERK和p38等信号通路的活性,进而影响细胞的生物学行为。

在多种疾病的发生和发展过程中,Map3k9的表达和功能发生改变。例如,在炎症性脱髓鞘疾病中,miR-20a通过靶向Map3k9抑制调节性T细胞(Treg)的分化,从而加重实验性自身免疫性脑脊髓炎(EAE)的病情[1]。此外,Map3k9还与自身炎症性疾病有关。例如,RIPK1(Receptor-interacting serine/threonine-protein kinase 1)的突变导致其不能被caspase-8切割,从而抑制了RIPK3和坏死性凋亡的激活,引起了一种称为“cleavage-resistant RIPK1-induced autoinflammatory syndrome”的自身炎症性疾病[2]。

在癌症研究中,Map3k9的表达和功能也受到关注。例如,circUGGT2通过上调Map3k9的表达,促进胃癌细胞增殖、侵袭和顺铂耐药性[3]。bta-miR-484通过靶向Map3k9,抑制牛肌肉内前脂肪细胞的增殖和凋亡,从而降低肌肉内脂肪含量[4]。circ_SIPA1L1通过上调Map3k9的表达,促进骨肉瘤细胞的增殖和侵袭[5]。miR-361-5p通过靶向Map3k9,诱导肝细胞癌细胞的凋亡并增强其对化疗药物的敏感性[6]。miR-148a-3p通过靶向Map3k9,抑制肺腺癌(LUAD)的进展[7]。miR-148a通过靶向Map3k9,抑制食管鳞状细胞癌(ESCC)的增殖和侵袭[8]。miR-125b-5p通过靶向Map3k9,抑制喉鳞状细胞癌(LSCC)细胞的增殖和糖代谢紊乱[9]。

综上所述,Map3k9作为一种重要的MAP3K家族成员,在多种生物学过程中发挥重要作用。Map3k9的表达和功能改变与多种疾病的发生和发展密切相关。深入研究Map3k9的生物学功能及其调控机制,有助于揭示疾病的发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Wang, Yishu, Xie, Chong, Song, Yaying, Ding, Jie, Guan, Yangtai. 2021. miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis. In Journal of translational medicine, 19, 223. doi:10.1186/s12967-021-02893-4. https://pubmed.ncbi.nlm.nih.gov/34039371/
2. Lalaoui, Najoua, Boyden, Steven E, Oda, Hirotsugu, Kastner, Daniel L, Silke, John. 2019. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. In Nature, 577, 103-108. doi:10.1038/s41586-019-1828-5. https://pubmed.ncbi.nlm.nih.gov/31827281/
3. Chen, Xiao-Yu, Yang, Yan-Ling, Yu, Yi, Zhang, Jing, Zhu, Jin-Shui. 2024. CircUGGT2 downregulation by METTL14-dependent m6A modification suppresses gastric cancer progression and cisplatin resistance through interaction with miR-186-3p/MAP3K9 axis. In Pharmacological research, 204, 107206. doi:10.1016/j.phrs.2024.107206. https://pubmed.ncbi.nlm.nih.gov/38729588/
4. Ma, Xinhao, Zhang, Dianqi, Yang, Zhimei, Mei, Chugang, Zan, Linsen. 2024. Bta-miR-484 regulates proliferation and apoptosis of bovine intramuscular preadipocytes via targeting MAP3K9 to inhibit the JNK signaling pathway. In International journal of biological macromolecules, 286, 138082. doi:10.1016/j.ijbiomac.2024.138082. https://pubmed.ncbi.nlm.nih.gov/39603290/
5. Jun, Liu, Xuhong, Li, Hui, Liu. 2020. Circ_SIPA1L1 Promotes Osteosarcoma Progression Via miR-379-5p/MAP3K9 Axis. In Cancer biotherapy & radiopharmaceuticals, 38, 604-618. doi:10.1089/cbr.2020.3891. https://pubmed.ncbi.nlm.nih.gov/32897735/
6. Ma, Xinhao, Zhang, Dianqi, Yang, Zhimei, Mei, Chugang, Zan, Linsen. 2024. bta-miR-484 Inhibits Bovine Intramuscular Adipogenesis by Regulating Mitotic Clonal Expansion via the MAP3K9/JNK/CCND1 Axis. In Journal of agricultural and food chemistry, 73, 1062-1074. doi:10.1021/acs.jafc.4c07956. https://pubmed.ncbi.nlm.nih.gov/39719059/
7. Ren, Qingbo, Xiao, Xiangmei, Leng, Xiaoqian, Ren, Ziyuan, Xiao, Hang. 2021. MicroRNA-361-5p induces hepatocellular carcinoma cell apoptosis and enhances drug sensitivity by targeting MAP3K9. In Experimental and therapeutic medicine, 21, 574. doi:10.3892/etm.2021.10006. https://pubmed.ncbi.nlm.nih.gov/33850546/
8. Liang, Lu, Xu, Wen-Yan, Shen, Ao, Huang, Jiong-Hua, Yu, Xi-Yong. 2022. Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. In Acta pharmacologica Sinica, 43, 2946-2955. doi:10.1038/s41401-022-00893-8. https://pubmed.ncbi.nlm.nih.gov/35388129/
9. Zhang, B-X, Yu, T, Yu, Z, Yang, X-G. . MicroRNA-148a regulates the MAPK/ERK signaling pathway and suppresses the development of esophagus squamous cell carcinoma via targeting MAP3K9. In European review for medical and pharmacological sciences, 23, 6497-6504. doi:10.26355/eurrev_201908_18533. https://pubmed.ncbi.nlm.nih.gov/31378889/