Ccdc63-flox 基因敲除小鼠

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产品名称

Ccdc63-flox 基因敲除小鼠

产品编号

S-CKO-10667

品系全称

C57BL/6JCya-Ccdc63em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-330188-Ccdc63-B6J-VA

品系状态

使用本品系发表的文献需注明: Ccdc63-flox 基因敲除小鼠 mice (Strain S-CKO-10667) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
coiled-coil domain containing 63
基因别称
4921511C16Rik
染色体号
Chr 5 (Mouse)
转录本 ID
NCBI: NM_183307.4 | Ensembl: ENSMUST00000058960
修饰方式
条件性基因敲除
靶向范围
Exon 5
敲除长度
~690 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:3607777Mice homozygous for a null allele exhibit male infertility, defects in sperm heads and impaired elongation of flagella with no motile spermatozoa.
Ccdc63,全称为coiled-coil domain-containing protein 63,是一种编码卷曲螺旋结构域的蛋白质的基因。卷曲螺旋结构域是一种常见的蛋白质结构,参与蛋白质的折叠和功能。Ccdc63基因的表达和功能研究在生殖、发育、疾病发生和细胞功能等多个领域具有重要意义。

在生殖领域,Ccdc63基因与精子的形成和功能密切相关。研究发现,Ccdc63基因在精子的尾形成过程中发挥重要作用,与精子的运动能力和受精能力密切相关[3]。此外,Ccdc63基因还参与精子的染色体浓缩和基因表达调控,影响精子的遗传物质传递[1]。

在发育领域,Ccdc63基因的表达与多种组织的发育过程相关。研究发现,Ccdc63基因在胚胎发育过程中发挥重要作用,参与细胞的分化和组织形成[5]。此外,Ccdc63基因还与骨骼发育和肌肉功能相关,参与骨骼生长和肌肉收缩的调控[2]。

在疾病发生领域,Ccdc63基因与多种疾病的发病机制相关。研究发现,Ccdc63基因的突变或异常表达与多种疾病的发生和发展相关,包括心肌梗死、高血压、慢性肾脏病和代谢综合征等[6,7,8]。此外,Ccdc63基因还与酒精依赖和酒精消耗相关,参与酒精代谢和酒精相关疾病的发生[4,9]。

综上所述,Ccdc63基因是一种编码卷曲螺旋结构域的蛋白质的基因,在生殖、发育、疾病发生和细胞功能等多个领域具有重要意义。Ccdc63基因的研究有助于深入理解其生物学功能和疾病发生机制,为相关疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Sarkar, Saumya, Yadav, Santosh, Mehta, Poonam, Gupta, Gopal, Rajender, Singh. 2022. Histone Methylation Regulates Gene Expression in the Round Spermatids to Set the RNA Payloads of Sperm. In Reproductive sciences (Thousand Oaks, Calif.), 29, 857-882. doi:10.1007/s43032-021-00837-3. https://pubmed.ncbi.nlm.nih.gov/35015293/
2. Li, Yongjin, Wang, Wei, Kong, Chao, Li, Chaoyi, Lu, Shibao. 2024. Identifying the miRNA-gene networks contributes to exploring paravertebral muscle degeneration's underlying pathogenesis and therapy strategy. In Heliyon, 10, e30517. doi:10.1016/j.heliyon.2024.e30517. https://pubmed.ncbi.nlm.nih.gov/38765163/
3. Young, Samantha A M, Miyata, Haruhiko, Satouh, Yuhkoh, Baker, Mark A, Ikawa, Masahito. 2015. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. In International journal of molecular sciences, 16, 24732-50. doi:10.3390/ijms161024732. https://pubmed.ncbi.nlm.nih.gov/26501274/
4. Baik, Inkyung, Cho, Nam H, Kim, Seong Hwan, Han, Bok-Ghee, Shin, Chol. 2011. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. In The American journal of clinical nutrition, 93, 809-16. doi:10.3945/ajcn.110.001776. https://pubmed.ncbi.nlm.nih.gov/21270382/
5. Gong, Jie, Li, Bijun, Zhao, Ji, Zhou, Tao, Xu, Peng. 2022. Sex-Specific Genomic Region Identification and Molecular Sex Marker Development of Rock Bream (Oplegnathus fasciatus). In Marine biotechnology (New York, N.Y.), 24, 163-173. doi:10.1007/s10126-022-10095-2. https://pubmed.ncbi.nlm.nih.gov/35122574/
6. Kong, Hang-Kin, Chan, Zoe, Yan, Sau-Woon, Wong, Ka-Hing, Lo, Chun-Lap. 2022. Revealing the species-specific genotype of the edible bird's nest-producing swiftlet, Aerodramus fuciphagus and the proteome of edible bird's nest. In Food research international (Ottawa, Ont.), 160, 111670. doi:10.1016/j.foodres.2022.111670. https://pubmed.ncbi.nlm.nih.gov/36076383/
7. Yamada, Yoshiji, Kato, Kimihiko, Oguri, Mitsutoshi, Takeuchi, Ichiro, Sakuma, Jun. 2018. Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. In International journal of molecular medicine, 42, 2415-2436. doi:10.3892/ijmm.2018.3852. https://pubmed.ncbi.nlm.nih.gov/30226566/
8. Lee, Ho-Sun, Kim, Yongkang, Park, Taesung. 2018. New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population. In Scientific reports, 8, 5701. doi:10.1038/s41598-018-23074-2. https://pubmed.ncbi.nlm.nih.gov/29632305/
9. Quillen, Ellen E, Chen, Xiang-Ding, Almasy, Laura, Kranzler, Henry R, Gelernter, Joel. 2013. ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. In American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 165B, 103-10. doi:10.1002/ajmg.b.32213. https://pubmed.ncbi.nlm.nih.gov/24277619/