Tox-flox 基因敲除小鼠

1. Scott, Andrew C, Dündar, Friederike, Zumbo, Paul, Philip, Mary, Schietinger, Andrea. 2019. TOX is a critical regulator of tumour-specific T cell differentiation. In Nature, 571, 270-274. doi:10.1038/s41586-019-1324-y. https://pubmed.ncbi.nlm.nih.gov/31207604/

2. Sekine, Takuya, Perez-Potti, André, Nguyen, Son, Betts, Michael R, Buggert, Marcus. . TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells. In Science immunology, 5, . doi:10.1126/sciimmunol.aba7918. https://pubmed.ncbi.nlm.nih.gov/32620560/

3. Wang, Xiaochen, He, Qifeng, Shen, Haiyuan, Yu, Weiwei, Sun, Beicheng. 2019. TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma. In Journal of hepatology, 71, 731-741. doi:10.1016/j.jhep.2019.05.015. https://pubmed.ncbi.nlm.nih.gov/31173813/

4. Seo, Hyungseok, Chen, Joyce, González-Avalos, Edahí, Bhandoola, Avinash, Rao, Anjana. 2019. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion. In Proceedings of the National Academy of Sciences of the United States of America, 116, 12410-12415. doi:10.1073/pnas.1905675116. https://pubmed.ncbi.nlm.nih.gov/31152140/

5. Yeckes, Alyson R, Victor, Aaron R, Zhu, Zheng, Bruce, Bethany, Kaye, Jonathan. . The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in Gene Regulation. In Journal of immunology (Baltimore, Md. : 1950), 210, 1889-1898. doi:10.4049/jimmunol.2200659. https://pubmed.ncbi.nlm.nih.gov/37115203/