Npbwr1-flox 基因敲除小鼠

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产品名称

Npbwr1-flox 基因敲除小鼠

产品编号

S-CKO-06924

品系全称

C57BL/6JCya-Npbwr1em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-226304-Npbwr1-B6J-VA

品系状态

使用本品系发表的文献需注明: Npbwr1-flox 基因敲除小鼠 mice (Strain S-CKO-06924) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
neuropeptides B/W receptor 1
基因别称
Gpr7,Nbpwr1
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_010342.1 | Ensembl: ENSMUST00000044180
修饰方式
条件性基因敲除
靶向范围
Exon 1
敲除长度
~1020 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:891989Homozygous null males develop adult-onset obesity, are hyperphagic, and have decreased energy expenditure and locomotor activity. Plasma levels of glucose, leptin and insulin are elevated in males.
Npbwr1,也称为neuropeptides B and W receptor-1,是一种G蛋白偶联受体,主要在中枢神经系统中表达,特别是在杏仁核、下丘脑和海马等与情绪、应激反应和认知功能相关的脑区。Npbwr1与神经肽B(NPB)和神经肽W(NPW)结合,参与调节神经递质的释放、神经元的兴奋性和神经元的可塑性等过程。

NPBWR1在多种神经精神疾病中发挥重要作用,包括抑郁症、焦虑症和社交障碍等。在抑郁症患者中,NPBWR1的表达水平升高,并且与抑郁症状的严重程度呈正相关。此外,NPBWR1的基因多态性与抑郁症的易感性相关,表明NPBWR1在抑郁症的发生和发展中发挥重要作用。

NPBWR1还参与调节能量代谢和脂肪细胞分化。研究表明,NPBWR1可以促进白色脂肪细胞的分化和成熟,而抑制棕色脂肪细胞的分化和成熟。此外,NPBWR1还参与调节胰岛素的分泌和葡萄糖的代谢,可能与糖尿病的发生和发展有关。

NPBWR1在心脏中也存在表达,参与调节心脏的神经内分泌功能和炎症反应。研究表明,NPBWR1可以抑制心脏细胞的增殖和分化,可能与心脏发育和疾病的发生有关。

此外,NPBWR1还参与调节生殖系统的功能。研究表明,NPBWR1在附睾中存在表达,参与调节精子的成熟和运动能力。此外,NPBWR1还参与调节卵巢癌的发生和发展,可能与卵巢癌的转移和侵袭有关。

综上所述,Npbwr1是一种重要的G蛋白偶联受体,参与调节神经递质的释放、神经元的兴奋性和神经元的可塑性等过程。Npbwr1在多种神经精神疾病、能量代谢和脂肪细胞分化、心脏功能和生殖系统功能中发挥重要作用。进一步研究Npbwr1的生物学功能和作用机制,有助于深入理解神经递质信号传导和神经精神疾病的发病机制,为相关疾病的治疗和预防提供新的思路和策略[1,2,3,4,5,6,7,8,9,10]。

参考文献:
1. Stein, Gregor, Aly, Janine S, Lange, Lisa, Hoffmann, Steve, Engmann, Olivia. 2024. Npbwr1 signaling mediates fast antidepressant action. In Molecular psychiatry, , . doi:10.1038/s41380-024-02790-4. https://pubmed.ncbi.nlm.nih.gov/39433904/
2. Soya, Shingo, Toda, Koji, Sakurai, Katsuyasu, Sakimura, Kenji, Sakurai, Takeshi. 2025. Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions. In Science advances, 11, eadn1335. doi:10.1126/sciadv.adn1335. https://pubmed.ncbi.nlm.nih.gov/39813346/
3. Dizon, Maria L V, deRegnier, Raye-Ann O, Weiner, Steven J, Saad, Antonio F, Caritis, Steve N. 2022. Differential Gene Expression in Cord Blood of Infants Diagnosed with Cerebral Palsy: A Pilot Analysis of the Beneficial Effects of Antenatal Magnesium Cohort. In Developmental neuroscience, 44, 412-425. doi:10.1159/000525483. https://pubmed.ncbi.nlm.nih.gov/35705018/
4. Liu, Shasha, Du, Qiuyue, Rao, Yang, Liu, Caiyan, Qu, Pengpeng. 2020. Long non-coding RNA NPBWR1-2 affects the development of ovarian cancer via multiple microRNAs. In Oncology letters, 20, 685-692. doi:10.3892/ol.2020.11639. https://pubmed.ncbi.nlm.nih.gov/32565993/
5. Wojciechowicz, T, Szczepankiewicz, D, Strowski, M Z, Nowak, K W, Skrzypski, M. 2023. Neuropeptide B promotes differentiation of rodent white preadipocytes into mature adipocytes. In Molecular and cellular endocrinology, 562, 111850. doi:10.1016/j.mce.2023.111850. https://pubmed.ncbi.nlm.nih.gov/36623583/
6. Pandey, Shashank, Tuma, Zdenek, Peroni, Elisa, Papini, Anna Maria, Chottova Dvorakova, Magdalena. 2020. Identification of NPB, NPW and Their Receptor in the Rat Heart. In International journal of molecular sciences, 21, . doi:10.3390/ijms21217827. https://pubmed.ncbi.nlm.nih.gov/33105700/
7. Wojciechowicz, Tatiana, Billert, Maria, Dhandapani, Priyavathi, Nowak, Krzysztof W, Skrzypski, Marek. 2021. Neuropeptide B promotes proliferation and differentiation of rat brown primary preadipocytes. In FEBS open bio, 11, 1153-1164. doi:10.1002/2211-5463.13128. https://pubmed.ncbi.nlm.nih.gov/33629519/
8. Watanabe, Noriya, Wada, Mari, Irukayama-Tomobe, Yoko, Sakurai, Takeshi, Yamamoto, Miyuki. 2012. A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions. In PloS one, 7, e35390. doi:10.1371/journal.pone.0035390. https://pubmed.ncbi.nlm.nih.gov/22545105/
9. Zhao, Wangsheng, Quansah, Eugene, Yuan, Meng, Yi, Chuanping, Cai, Xin. 2019. Region-specific gene expression in the epididymis of Yak. In Theriogenology, 139, 132-146. doi:10.1016/j.theriogenology.2019.08.006. https://pubmed.ncbi.nlm.nih.gov/31404823/
10. Ziolkowska, Agnieszka, Rucinski, Marcin, Tyczewska, Marianna, Malendowicz, Ludwik K. . Neuropeptide B (NPB) and neuropeptide W (NPW) system in cultured rat calvarial osteoblast-like (ROB) cells: NPW and NPB inhibit proliferative activity of ROB cells. In International journal of molecular medicine, 24, 781-7. doi:. https://pubmed.ncbi.nlm.nih.gov/19885618/