Ermp1-flox 基因敲除小鼠

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产品名称

Ermp1-flox 基因敲除小鼠

产品编号

S-CKO-06894

品系全称

C57BL/6JCya-Ermp1em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-226090-Ermp1-B6J-VA

品系状态

使用本品系发表的文献需注明: Ermp1-flox 基因敲除小鼠 mice (Strain S-CKO-06894) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
endoplasmic reticulum metallopeptidase 1
基因别称
D19Ertd410e,D19Wsu12e,Fxna,b2b2633Clo,mKIAA1815
染色体号
Chr 19 (Mouse)
转录本 ID
NCBI: NM_001081213 | Ensembl: ENSMUST00000159692
修饰方式
条件性基因敲除
靶向范围
Exon 2
敲除长度
~1.4 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:106250Mice homozygous for an ENU-induced mutation exhibit cardiovascular defects including double outlet right ventricle, aortic arch anomalies and vascular ring, as well as anopthalmia, renal dysplasia, and craniofacial anomalies including short snout, cleft palate and cleft lip.
ERMP1,也称为Endoplasmic Reticulum Metallo Protease 1,是一种重要的内质网金属蛋白酶。它参与细胞内蛋白质的加工和降解,影响细胞功能和生物学过程。ERMP1在多种生物学过程中发挥作用,包括细胞增殖、迁移、凋亡和氧化应激响应等。

ERMP1在多种癌症中发挥重要作用,包括口腔癌、肺癌、子宫内膜癌、肾细胞癌和乳腺癌。在口腔癌中,ERMP1的表达与肿瘤的侵袭性和预后不良相关[9]。在肺癌中,ERMP1的表达与肿瘤的增殖和迁移相关[2]。在子宫内膜癌中,ERMP1的表达与肿瘤的增殖和氧化应激响应相关[3]。在肾细胞癌中,ERMP1的表达与肿瘤的进展和预后相关[1,8]。在乳腺癌中,ERMP1的表达与肿瘤的增殖和侵袭性相关[6]。

此外,ERMP1还与多种疾病相关,包括早期发作的家族性阿尔茨海默病、圆锥形角膜和胰岛素抵抗等。在早期发作的家族性阿尔茨海默病中,ERMP1基因的拷贝数变异与疾病的发生和进展相关[5]。在圆锥形角膜中,ERMP1基因的变异与疾病的发生相关[7]。在胰岛素抵抗中,ERMP1基因的表达与胰岛素信号通路相关[4]。

综上所述,ERMP1是一种重要的内质网金属蛋白酶,参与细胞内蛋白质的加工和降解,影响细胞功能和生物学过程。ERMP1在多种癌症和疾病中发挥重要作用,包括口腔癌、肺癌、子宫内膜癌、肾细胞癌和乳腺癌。ERMP1的研究有助于深入理解内质网金属蛋白酶的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Jing, Xiao, Xu, Gang, Gong, Yu, Li, Zhongyi, Pan, Shouhua. 2021. A five-gene methylation signature predicts overall survival of patients with clear cell renal cell carcinoma. In Journal of clinical laboratory analysis, 35, e24031. doi:10.1002/jcla.24031. https://pubmed.ncbi.nlm.nih.gov/34716619/
2. Wang, Qilin, Zhang, Junyou, Wen, Yanling, Liu, Qian, Li, Chunyan. 2024. The pleiotropic enhancer enh9 promotes cell proliferation and migration in non-small cell lung cancer via ERMP1 and PD-L1. In Biochimica et biophysica acta. Molecular basis of disease, 1870, 167015. doi:10.1016/j.bbadis.2023.167015. https://pubmed.ncbi.nlm.nih.gov/38182069/
3. Qu, Jinfeng, Zhang, Lei, Li, Lanyu, Su, Yujie. 2018. miR-148b Functions as a Tumor Suppressor by Targeting Endoplasmic Reticulum Metallo Protease 1 in Human Endometrial Cancer Cells. In Oncology research, 27, 81-88. doi:10.3727/096504018X15202988139874. https://pubmed.ncbi.nlm.nih.gov/29523216/
4. Li, Yuanyuan, Li, Dongmei, Cheng, Xingbo. 2021. The association between expression of lncRNAs in patients with GDM. In Endocrine connections, 10, 1080-1090. doi:10.1530/EC-21-0227. https://pubmed.ncbi.nlm.nih.gov/34289446/
5. Hooli, B V, Kovacs-Vajna, Z M, Mullin, K, Bertram, L, Tanzi, R E. 2013. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. In Molecular psychiatry, 19, 676-81. doi:10.1038/mp.2013.77. https://pubmed.ncbi.nlm.nih.gov/23752245/
6. Wu, J, Liu, S, Liu, G, Ethier, S P, Yang, Z-Q. 2011. Identification and functional analysis of 9p24 amplified genes in human breast cancer. In Oncogene, 31, 333-41. doi:10.1038/onc.2011.227. https://pubmed.ncbi.nlm.nih.gov/21666724/
7. Li, Xingyong, Yao, Yinghao, Xing, Shilai, Zhou, Yang, Chen, Shihao. 2025. Subclinical parents assist in the detection of genetic variants in keratoconus by trio-based whole-exome sequencing. In Molecular vision, 31, 23-32. doi:. https://pubmed.ncbi.nlm.nih.gov/40098727/
8. Lu, Wenjun, Liu, Hengchen, Zhang, Xin, Yang, Shulong, Li, Zhaozhu. 2022. A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma. In Computational and mathematical methods in medicine, 2022, 8504441. doi:10.1155/2022/8504441. https://pubmed.ncbi.nlm.nih.gov/35529267/
9. Huang, Zijing, Lan, Tianjun, Wang, Junjie, Chen, Zhifeng, Zhang, Xiaolei. . Identification and validation of seven RNA binding protein genes as a prognostic signature in oral cavity squamous cell carcinoma. In Bioengineered, 12, 7248-7262. doi:10.1080/21655979.2021.1974328. https://pubmed.ncbi.nlm.nih.gov/34585646/