Tec-flox 基因敲除小鼠

1. Heidegger, Isabel, Fotakis, Georgios, Offermann, Anne, Wolf, Dominik, Pircher, Andreas. 2022. Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer. In Molecular cancer, 21, 132. doi:10.1186/s12943-022-01597-7. https://pubmed.ncbi.nlm.nih.gov/35717322/

2. Lim, Bobae, Jun, Hee Jung, Kim, Ah-young, Choi, JeeHyun, Kim, Jungho. 2012. The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC. In Carcinogenesis, 33, 1450-8. doi:10.1093/carcin/bgs164. https://pubmed.ncbi.nlm.nih.gov/22581839/

3. Kim, Ah-Young, Lim, Bobae, Choi, JeeHyun, Kim, Jungho. 2015. The TFG-TEC oncoprotein induces transcriptional activation of the human β-enolase gene via chromatin modification of the promoter region. In Molecular carcinogenesis, 55, 1411-23. doi:10.1002/mc.22384. https://pubmed.ncbi.nlm.nih.gov/26310886/

4. Lowe, Jacques, Joseph, Raji E, Andreotti, Amy H. 2022. Conformational switches that control the TEC kinase - PLCγ signaling axis. In Journal of structural biology: X, 6, 100061. doi:10.1016/j.yjsbx.2022.100061. https://pubmed.ncbi.nlm.nih.gov/35128378/