Ascl2-flox 基因敲除小鼠

1. Basu, Sayon, Gavert, Nancy, Brabletz, Thomas, Ben-Ze'ev, Avri. 2018. The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression. In Cancer letters, 424, 9-18. doi:10.1016/j.canlet.2018.03.022. https://pubmed.ncbi.nlm.nih.gov/29551399/

2. Chen, Chia-Chun, Tran, Wendy, Song, Kai, Witte, Owen N, Graeber, Thomas G. 2023. Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation. In Cancer cell, 41, 2066-2082.e9. doi:10.1016/j.ccell.2023.10.009. https://pubmed.ncbi.nlm.nih.gov/37995683/

3. Shang, Yangyang, Jiang, Tao, Ran, Lijian, Chen, Lei, Wang, Rongquan. 2022. TET2-BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter. In The Journal of biological chemistry, 298, 102095. doi:10.1016/j.jbc.2022.102095. https://pubmed.ncbi.nlm.nih.gov/35660018/