Mical1-flox 基因敲除小鼠

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产品名称

Mical1-flox 基因敲除小鼠

产品编号

S-CKO-03644

品系全称

C57BL/6JCya-Mical1em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-171580-Mical1-B6J-VA

品系状态

使用本品系发表的文献需注明: Mical1-flox 基因敲除小鼠 mice (Strain S-CKO-03644) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
microtubule associated monooxygenase, calponin and LIM domain containing 1
基因别称
MICAL,MICAL-1,Nical
染色体号
Chr 10 (Mouse)
转录本 ID
NCBI: NM_138315 | Ensembl: ENSMUST00000019967
修饰方式
条件性基因敲除
靶向范围
Exon 8~12
敲除长度
~2.2 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2385847Homozygous KO leads to increased mortality after cardiac stress. Mice show impaired lamina-specific targeting of mossy fibre axons onto CA3 pyramidal neurons in the developing hippocampus.
MICAL1,也称为Molecule Interacting with CasL 1,是一种关键的蛋白质,参与细胞运动、轴突指导、细胞骨架动力学和基因转录等多种生物学过程。MICAL1通过氧化肌动蛋白的特定甲硫氨酸残基,调节肌动蛋白细胞骨架的重组,从而影响细胞形态和迁移[3]。此外,MICAL1还在神经元发育过程中发挥重要作用,通过与Semaphorin轴突导向蛋白相互作用,产生活性氧,氧化肌动蛋白,导致肌动蛋白丝的解聚和神经元生长锥动力学的改变[7]。

MICAL1在多种癌症中发挥重要作用。在胰腺癌中,MICAL1的表达上调,通过激活WNT/β-catenin信号通路促进肿瘤细胞的增殖、迁移和侵袭[1]。在结直肠癌中,MICAL1的表达下调,通过抑制EGR1/β-catenin信号通路抑制肿瘤细胞的迁移和增殖[4]。此外,MICAL1在急性髓系白血病中的表达上调,与临床预后和免疫浸润相关[6]。

MICAL1的突变与某些疾病的发生和发展相关。例如,MICAL1的突变与常染色体显性外侧颞叶癫痫(ADLTE)相关,突变导致酶活性增加,促进细胞收缩[2]。此外,MICAL1的突变还与良性儿童癫痫相关,突变可能通过改变MICAL1的5'UTR结构,影响其翻译[5]。

综上所述,MICAL1是一种重要的蛋白质,参与细胞骨架动力学、神经元发育和多种癌症的发生和发展。MICAL1的研究有助于深入理解其在生物学过程中的作用和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Cai, Kun, Deng, Lu, Zheng, Dijie, He, Zhiwei, Yu, Chao. 2022. MICAL1 facilitates pancreatic cancer proliferation, migration, and invasion by activating WNT/β-catenin pathway. In Journal of translational medicine, 20, 528. doi:10.1186/s12967-022-03749-1. https://pubmed.ncbi.nlm.nih.gov/36371204/
2. Haikazian, Sipan, Olson, Michael F. 2022. MICAL1 Monooxygenase in Autosomal Dominant Lateral Temporal Epilepsy: Role in Cytoskeletal Regulation and Relation to Cancer. In Genes, 13, . doi:10.3390/genes13050715. https://pubmed.ncbi.nlm.nih.gov/35627100/
3. McGarry, David J, Armstrong, Garett, Castino, Giovanni, Blyth, Karen, Olson, Michael F. 2021. MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. In Cancer letters, 519, 226-236. doi:10.1016/j.canlet.2021.07.039. https://pubmed.ncbi.nlm.nih.gov/34314753/
4. Gu, Huanyu, Li, Yi, Cui, Xiuping, Wang, Yu, Wen, Pushuai. 2021. MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway. In Biochemical pharmacology, 195, 114870. doi:10.1016/j.bcp.2021.114870. https://pubmed.ncbi.nlm.nih.gov/34902339/
5. Yang, Haiyan, Liao, Hongmei, Gan, Siyi, Xiao, Ting, Wu, Liwen. 2024. A novel splicing variant in MICAL-1 gene is associated with epilepsy. In European journal of medical genetics, 69, 104946. doi:10.1016/j.ejmg.2024.104946. https://pubmed.ncbi.nlm.nih.gov/38705457/
6. Song, Yinsen, Yang, Zhenzhen, Gao, Na, Zhang, Bojun. 2024. MICAL1 promotes the proliferation in acute myeloid leukemia and is associated with clinical prognosis and immune infiltration. In Discover oncology, 15, 279. doi:10.1007/s12672-024-01150-6. https://pubmed.ncbi.nlm.nih.gov/38995414/
7. Micovic, Katarina, Canuel, Alicia, Remtulla, Aasiya, McGarry, David J, Olson, Michael F. . Mical1 deletion in tyrosinase expressing cells affects mouse running gaits. In Genes, brain, and behavior, 23, e70004. doi:10.1111/gbb.70004. https://pubmed.ncbi.nlm.nih.gov/39344934/